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A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

Academic Journal

Hansen, J.N.; Kaiser, F.; Leyendecker, P.; Stüven, B.; Krause, J.-H.; Derakhshandeh, F.; Wachten, D.; Irfan, J.; Henderson, D.J.P.; Sroka, T.J.; Mick, D.U.; Preval, K.M.; Desai, P.B.; Pazour, G.J.; Kraut, M.; Theis, H.; Drews, A.-D.; De-Domenico, E.; Händler, K.

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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

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Omar, F.; Findlay, J.E.; Carfray, G.; Allcock, R.W.; Jiang, Z.; Moore, C.; Muir, A.L.; Bowers, K.; Adam, J.M.; Adams, D.R.; Houslay, M.D.; Henderson, D.J.P.; Lannoy, M.; Ong, A.C.M.; Fertig, B.A.; Baillie, G.S.; Mai, D.; Schwiebert, E.; Day, J.P.; Bolger, G.; Klussmann, E.; Pyne, N.J.

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Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)

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Henderson, D.J.P.; Houslay, M.D.; Bangma, C.H.; Hoffmann, R.

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The β-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP) ribosylation

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Henderson, D.J.P.; Emerson, B.M.; Miranda

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Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

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Böttcher, R.; Jenster, G.; Henderson, D.J.P.; Baillie, G.S.; Hoffmann, R.; Dulla, K.; Van Strijp, D.; Waanders, L.F.; Tevz, G.; Merkle, D.; Lehman, M.L.; Van Leenders, G.J.L.H.; Houslay, M.D.

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The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

Academic Journal

Henderson, D.J.P.; Byrne, A.; Baillie, G.S.; Dulla, K.; Hoffmann, R.; Jenster, G.; Houslay, M.D.

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Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression

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Huston, E.; Houslay, M.D.; Sheppard, C.L.; Lee, L.C.Y.; Hill, E.V.; Henderson, D.J.P.; Anthony, D.F.; Houslay, D.M.; Yalla, K.C.; Cairns, L.S.; Dunlop, A.J.; Baillie, G.S.

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Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

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Mackenzie, K.F.; Wallace, D.A.; Hill, E.V.; Anthony, D.F.; Henderson, D.J.P.; Houslay, D.M.; Baillie, G.S.; Houslay, M.D.; Arthur, J.S.C.

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