e-Article
Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial
Document Type
article
Author
Kempen, John H; Van Natta, Mark L; Altaweel, Michael M; Dunn, James P; Jabs, Douglas A; Lightman, Susan L; Thorne, Jennifer E; Holbrook, Janet T; Jaffe, Glenn J; Branchaud, Brenda; Hahn, Paul; Koreen, Larry; Lad, Eleonora M; Lin, Phoebe; Martel, Joseph Nissim; Serrano, Neha; Skalak, Cindy; Vajzovic, Lejla; Baer, Claxton; Bryant, Joyce; Chavala, Sai; Cusick, Michael; Day, Shelley; Dayani, Pouya; Ehlers, Justis; Kesen, Muge; Lee, Annie; Melamud, Alex; Qureshi, Jawad A; Scott, Adrienne Williams; See, Robert F; Shuler, Robert K; Wood, Megan; Yeh, Steven; Fernandes, Alcides; Gibbs, Deborah; Leef, Donna; Martin, Daniel F; Srivastava, Sunil; Begum, Hosne; Boring, Jeff; Brotherson, Kristen L; Burkholder, Bryn; Butler, Nicholas J; Cain, Dennis; Cook, Mary A; Emmert, David; Graul, Janis R; Herring, Mark; Laing, Ashley; Leung, Theresa G; Mahon, Michael C; Moradi, Ahmafreza; Nwankwo, Antonia; Ostheimer, Trucian L; Reed, Terry; Arnold, Ellen; Barnabie, Patricia M; Belair, Marie-Lynn; Bolton, Stephen G; Brodine, Joseph B; Brown, Diane M; Brune, Lisa M; Galor, Anat; Gan, Theresa; Jacobowitz, Adam; Kapoor, Meera; Kedhar, Sanjay; Kim, Stephen; Leder, Henry A; Livingston, Alison G; Morton, Yavette; Nolan, Kisten; Peters, George B; Soto, Priscilla; Stevenson, Ricardo; Tarver-Carr, Michelle; Wang, Yue; Foster, C Stephen; Anesi, Stephen D; Bruner, Linda; Ceron, Olga; Hinkle, David M; Persons, Nancy; Wentworth, Bailey; Acevedo, Sarah; Anzaar, Fahd; Cesca, Tom; Contero, Angelica; Fitzpatrick, Kayleigh; Goronga, Faith; Johnson, Jyothir; Lebron, Karina Q; Marvell, Danielle; Morgan, Chandra; Patel, Nita; Pinto, Jennifer; Siddique, Sana S; Sprague, Janet
Source
American Journal of Ophthalmology. 160(6)
Subject
Language
Abstract
PurposeTo identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes.DesignCohort study using randomized controlled trial data.MethodsMulticenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA.ResultsBaseline factors significantly associated with reduced BCVA included age ≥50 vs 10 vs grade 0; cataract; macular thickening; and exudative retinal detachment. Over 2 years, eyes better than 20/50 and 20/50 or worse at baseline improved, on average, by 1 letter (P = .52) and 10 letters (P < .001), respectively. Both treatment groups and all sites of uveitis improved similarly. Factors associated with improved BCVA included resolution of active AC cells, resolution of macular thickening, and cataract surgery in an initially cataractous eye. Factors associated with worsening BCVA included longer duration of uveitis (6-10 or >10 vs