e-Article
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
Document Type
article
Author
Keaton, Jacob; Kamali, Zoha; Xie, Tian; Vaez, Ahmad; Williams, Ariel; Goleva, Slavina; Ani, Alireza; Evangelou, Evangelos; Hellwege, Jacklyn; Yengo, Loic; Young, William; Traylor, Matthew; Giri, Ayush; Zheng, Zhili; Zeng, Jian; Chasman, Daniel; Morris, Andrew; Caulfield, Mark; Hwang, Shih-Jen; Kooner, Jaspal; Conen, David; Attia, John; Morrison, Alanna; Loos, Ruth; Kristiansson, Kati; Schmidt, Reinhold; Hicks, Andrew; Pramstaller, Peter; Nelson, Christopher; Samani, Nilesh; Risch, Lorenz; Gyllensten, Ulf; Melander, Olle; Riese, Harriette; Wilson, James; Campbell, Harry; Rich, Stephen; Psaty, Bruce; Lu, Yingchang; Guo, Xiuqing; Rice, Kenneth; Vollenweider, Peter; Sundström, Johan; Langenberg, Claudia; Tobin, Martin; Giedraitis, Vilmantas; Luan, Jianan; Tuomilehto, Jaakko; Kutalik, Zoltan; Ripatti, Samuli; Salomaa, Veikko; Girotto, Giorgia; Trompet, Stella; Jukema, J; van der Harst, Pim; Ridker, Paul; Giulianini, Franco; Vitart, Veronique; Goel, Anuj; Watkins, Hugh; Harris, Sarah; Deary, Ian; van der Most, Peter; Oldehinkel, Albertine; Keavney, Bernard; Hayward, Caroline; Campbell, Archie; Boehnke, Michael; Scott, Laura; Boutin, Thibaud; Mamasoula, Chrysovalanto; Järvelin, Marjo-Riitta; Peters, Annette; Gieger, Christian; Lakatta, Edward; Cucca, Francesco; Hui, Jennie; Knekt, Paul; Enroth, Stefan; De Borst, Martin; Polašek, Ozren; Concas, Maria; Catamo, Eulalia; Cocca, Massimiliano; Li-Gao, Ruifang; Hofer, Edith; Schmidt, Helena; Spedicati, Beatrice; Waldenberger, Melanie; Strachan, David; Laan, Maris; Teumer, Alexander; Dörr, Marcus; Gudnason, Vilmundur; Cook, James; Ruggiero, Daniela; Kolcic, Ivana; Boerwinkle, Eric; Traglia, Michela; Lehtimäki, Terho
Source
Nature Genetics. 56(5)
Subject
Language
Abstract
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P