e-Article
The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder
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article
Author
de Zwarte, Sonja MC; Brouwer, Rachel M; Agartz, Ingrid; Alda, Martin; Aleman, André; Alpert, Kathryn I; Bearden, Carrie E; Bertolino, Alessandro; Bois, Catherine; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth EL; Cahn, Wiepke; Cannon, Dara M; Cannon, Tyrone D; Caseras, Xavier; Castro-Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; De la Serna, Elena; Di Giorgio, Annabella; Doucet, Gaelle E; Eker, Mehmet Cagdas; Erk, Susanne; Fears, Scott C; Foley, Sonya F; Frangou, Sophia; Frankland, Andrew; Fullerton, Janice M; Glahn, David C; Goghari, Vina M; Goldman, Aaron L; Gonul, Ali Saffet; Gruber, Oliver; de Haan, Lieuwe; Hajek, Tomas; Hawkins, Emma L; Heinz, Andreas; Hillegers, Manon HJ; Pol, Hilleke E Hulshoff; Hultman, Christina M; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik G; Kane, Fergus; Kempton, Matthew J; Koenis, Marinka MG; Kopecek, Miloslav; Krabbendam, Lydia; Krämer, Bernd; Lawrie, Stephen M; Lenroot, Rhoshel K; Marcelis, Machteld; Marsman, Jan-Bernard C; Mattay, Venkata S; McDonald, Colm; Meyer-Lindenberg, Andreas; Michielse, Stijn; Mitchell, Philip B; Moreno, Dolores; Murray, Robin M; Mwangi, Benson; Najt, Pablo; Neilson, Emma; Newport, Jason; van Os, Jim; Overs, Bronwyn; Ozerdem, Aysegul; Picchioni, Marco M; Richter, Anja; Roberts, Gloria; Aydogan, Aybala Saricicek; Schofield, Peter R; Simsek, Fatma; Soares, Jair C; Sugranyes, Gisela; Toulopoulou, Timothea; Tronchin, Giulia; Walter, Henrik; Wang, Lei; Weinberger, Daniel R; Whalley, Heather C; Yalin, Nefize; Andreassen, Ole A; Ching, Christopher RK; van Erp, Theo GM; Turner, Jessica A; Jahanshad, Neda; Thompson, Paul M; Kahn, René S; van Haren, Neeltje EM
Source
Biological Psychiatry. 86(7)
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Language
Abstract
BackgroundSchizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.MethodsWe performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.ResultsFDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d