e-Article
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
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Abstract
Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cel