e-Article
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion
Document Type
redif-article
Author
Source
Nature, Nature. 438(7064):99-102
Subject
Language
English
Abstract
Anti-HIV microbicide A trial of three inhibitors of HIV-1 entry into target cells, administered vaginally in macaque monkeys prior to intercourse, shows that they can protect against infection by a simian-human immunodeficiency virus. One molecule, the antiviral CMPD 167, is particularly potent, providing protection when applied 6 hours before challenge. The macaque model is a proven test of AIDS prevention strategies, so these findings bode well for the prospects of similar compounds in humans.