부산대학교 도서관

Introduction: Patients without standard modifiable cardiovascular risk factors (SMuRF; hypertension, diabetes, hypercholesterolaemia, smoking) have worse outcomes in Type 1 acute myocardial infarction (AMI). The relationship between type 2 AMI (T2AMI) and outcomes in patients with and without SMuRF is unknown. This study aimed to determine the prevalence, characteristics and clinical outcomes of patients hospitalized with T2AMI based on the presence of SMuRF.Methods: All hospitalizations with a primary discharge diagnosis of T2AMI in the National Inpatient Sample were stratified according to SMuRF status (SMuRF and SMURF-less). Primary outcome was all-cause mortality while secondary outcomes were major adverse cardiovascular and cerebrovascular events (MACCE), major bleeding and ischemic stroke. Multivariable logistic regression was used to determine adjusted odds ratios (aOR) with 95% confidence intervals (95% CI).Results: Among 17,595 included hospitalizations, 1,345 (7.6%) were SMuRF-less. After multivariable adjustment, SMuRF-less patients were more likely to develop all-cause mortality (aOR 2.43, 95% CI 1.83 to 3.23), MACCE (aOR 2.32, 95% CI 1.79 to 2.90) and ischaemic stroke (aOR 2.57, 95% CI 1.56 to 4.24) compared to their SMuRF counterparts (Figure 1).Conclusions: T2AMI in the absence of SMuRF was associated with worse in-hospital outcomes compared to SMuRF-less patients. Further longitudinal studies are necessary to define the impact of SMuRF on longer term T2AMI outcomes.