e-Article
Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study*
Document Type
Academic Journal
Author
Emeriaud, Guillaume; Pons-Òdena, Marti; Bhalla, Anoopindar K.; Shein, Steven L.; Killien, Elizabeth Y.; Modesto i Alapont, Vicent; Rowan, Courtney; Baudin, Florent; Lin, John C.; Grégoire, Gabrielle; Napolitano, Natalie; Mayordomo-Colunga, Juan; Diaz, Franco; Cruces, Pablo; Medina, Alberto; Smith, Lincoln; Khemani, Robinder G.; Sforza, Jesica; Poterala, Rossana; Fernandez, Analia; Avila Vera, Antonio; Orqueda, Daniel; Agueda Vidal, Nilda; Rosemary, Deheza; Turon, Gonzalo; Monjes, Cecilia; Espanol, Segundo Fernando; Serrate, Alejandro Siaba; Iolster, Thomas; Torres, Silvio; Cinquegrani, Karina; Jose Montes, Maria; Capocasa, Patricia; Ferreyra, Marcela; Castellani, Pablo; Giampieri, Martin; Pedraza, Claudia; Landry, Luis Martin; Althabe, Maria; Fortini, Yanina Vanesa; Botta, Priscila; Paziencia, Fernando; Erickson, Simon; Barr, Samantha; Shea, Sara; Butt, Warwick; Delzoppo, Carmel; Pintimalla, Alyssa; Leon, Alejandro Fabio Martinez; Rivera, Gustavo Alfredo Guzman; Jouvet, Philippe; Emeriaud, Guillaume; Dumitrascu, Mariana; Ellen French, Mary; Caro I, Daniel; Castillo, Andres E.; Romero, Pablo Cruces; Medina, Tania; Madrid, Paula Pavez; Cortez, Ambar; Alvear, Jimena; Acuna, Carlos; Diaz, Franco; Nunez, Maria Jose; Araya, Adriana Wegner; Mundaca, Loreto Godoy; Chen, Yang; Lozano, German Perez; Carrero, Rosalba Pardo; Alarcon, Yurika Paola Lopez; Vega, Liliana Mazzillo; Izquierdo, Ledys Maria; Olave, Byron Enrique Piñeres; Orrego, Cesar Zuluaga; Lopez, Deyanira Quinonez; Hoyos, Pablo Vasquez; Vavrina, Martin; Zurek, Jiri; Campos-Miño, Santiago; Yerovi, Rocio; Bridier, Armelle; Payen, Valerie; Milesi, Christophe; Bourgoin, Pierre; Travert, Brendan; Genuini, Mathieu; Starck, Julie; Maria, Matthieu; Guichoux, Julie; Baudin, Florent; Briassoulis, George; Ilia, Stavroula; Di Nardo, Matteo; Camporesi, Anna; Chiusolo, Fabrizio; Shime, Nobuaki; Ohshimo, Shinichiro; Kida, Yoshiko; Kyo, Michihito; Tabata, Yuichi; Tang, Swee Fong; Tai, Chian Wern; Lum, Lucy Chai See; Elghuwael, Ismail; Rivera, Nestor Javier Jimenez; Jarillo Quijada, Alberto E; Kneyber, Martin; Dijkstra, Sandra; Beca, John; Sherring, Claire; Rea, Miriam; Vargas G, Sonia I; Miranda, Daniel Vasquez; Cortez, Grimaldo Ramirez; Tantalean, Jose; Pagowska-Klimek, Izabela; Escobar, Carlos Gil; Moniz, Marta Sousa; Camilo, Cristina; Hazwani, Tarek; Aldairi, Nedaa; Al Amoudi, Ahmed; Alahmadti, Ahmad; Taylor, Ryan; Mendizabal, Mikel; Orayen, Concepcion Goni; Fernandez, Yolanda Lopez; Valle, Juan Ramon; Martinez, Lidia; Orive, Javier Pilar; Brezmes, Marta; Lopez-Herce, Jesus; Parrilla, Julio; Gaboli, Mirella; Gomez, Jose Manuel Gonzalez; Morales Martinez, Antonio; Alapont, Vicent Modesto I; Diaz, Juan Ignacio Sanchez; Llorente de la Fuente, Ana M.; Palanca Arias, Daniel; Madurga Revilla, Paula; Martinez de Azagra, Amelia; Garcia Gonzalez, Maria; Arjona Villanueva, David; Garcia Casas, Paula; Brio Sanagustin, Sonia; Pons Odena, Marti; Medina, Alberto; Onate Vergara, Eider; Rodriguez Campoy, Patricia; Reyes Dominguez, Susana; Dursun, Oguz; Atike Ongun, Ebru; Kamit Can, Fulya; Berna Anil, Ayse; Baines, Paul; Walsh, Laura; Jones, Dawn; Sadasivam, Kalaimaran; Mildner, Reinout; Plunkett, Adrian; Lillie, Jon; Tibby, Shane; Wellman, Paul; Belfield, Holly; Brierley, Joe; Dominguez, Troy E.; Abaleke, Eugenia; Feinstein, Yael; Deep, Akash; Sundararajan, Santosh; Oruganti, Siva; Silvestre, Catarina; Weitz, James; Sheward, Victoria; Macrae, Duncan; Aramburo, Angela; Fortune, Peter-Marc; Subramanian, Gayathri; Jennings, Claire; Dwarakanathan, Buvana; Inwald, David; Feather, Calandra; Agbeko, Rachel; Lawton-Woodhall, Angela; McIntyre, Karen; Sykes, Kim; Pappachan, Jon; Gale, Helen; Mellish, Christie; McCorkell, Jenni; Torero, Luis; Nofziger, Ryan; Latifi, Samir; Anthony, Heather; Sanders, Ron; Hefley, Glenda; Virk, Manpreet; Jaimon, Nancy; Maddux, Aline B.; Mourani, Peter M.; Ralston, Kimberly; Sierra, Yamila; Khemani, Robinder; Newth, Christopher; Bhalla, Anoopindar; Kwok, Jeni; Morzov, Rica; Mahapatra, Sidharth; Truemper, Edward; Kustka, Lucinda; Nett, Sholeen T.; Singleton, Marcy; Dean Jarvis, J.; Yehya, Nadir; Napolitano, Natalie; Murphy, Marie; Ronan, Laurie; Morgan, Ryan; Kubis, Sherri; Broden, Elizabeth; Willson, Douglas; Henderson, Grace; Gedeit, Rainer; Murkowski, Kathy; Woods, Katherine; Kasch, Mary; Han, Yong Y; Affolter, Jeremy T; Tieves, Kelly S; Hughes-Schalk, Amber; Chima, Ranjit S.; Krallman, Kelli; Stoneman, Erin; Benken, Laura; Yunger, Toni; Schneider, James; Sweberg, Todd; Kessel, Aaron; Carroll, Christopher L.; Santanelli, James; Ackerman, Kate G; Cullimore, Melissa; Rowan, Courtney; Bales, Melissa; Keith Dockery, W.; Jafari-Namin, Shirin; Barry, Dana; Jane’t, Keary; Alibrahim, Omar; Patankar, Nikhil; Qiao, Haiping; Gertz, Shira; Su, Felice; Haileselassie, Bereketeab; Song, Hanqiu; Bysani, Kris; Monjure, Tracey; Beltramo, Fernando; Totapally, Balagangadhar; Govantes, Beatriz; Coates, Bria; Wellisch, Lawren; Allen, Kiona; Shukla, Avani; Thomas, Neal J.; Spear, Debbie; Shein, Steven L.; Gertz, Shira; Parker, Margaret M.; Sloniewsky, Daniel; Allen, Christine; Harrell, Amy; Pinto, Neethi; Kniola, Allison; Rodgers, Chiara; Cvijanovich, Natalie; Typpo, Katri; Kelley, Connor; King, Caroline; Sapru, Anil; Ratiu, Anna; Ashtari, Neda; Sikora, Lindsay; Jeyapalan, Asumthia S.; Coronado-Munoz, Alvaro; Flori, Heidi; Dahmer, Mary K.; Jayachandran, Chaandini; Hume, Janet; Nerheim, Dan; Smith, Rebecca; Spaeder, Michael; Adu-Darko, Michelle; Smith, Lincoln; Hartmann, Silvia; Sullivan, Erin; Merritt, Courtney; Al-Subu, Awni; Blom, Andrea; Lin, John C.; Spinella, Philip; Hsing, Deyin D.; Pon, Steve; Brian Estil, Jim; Gautam, Richa; Giuliano, John S., Jr; Tala, Joana
Source
Pediatric Critical Care Medicine. Sep 01, 2023 24(9):715-726
Subject
Language
English
ISSN
1529-7535
Abstract
OBJECTIVES:: The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use and associated clinical outcomes in PARDS. DESIGN:: Planned ancillary study to the 2016/2017 prospective Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology study. SETTING:: One hundred five international PICUs. PATIENTS:: Patients with newly diagnosed PARDS admitted during 10 study weeks. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: Children were categorized by their respiratory support at PARDS diagnosis into NIV or invasive mechanical ventilation (IMV) groups. Of 708 subjects with PARDS, 160 patients (23%) received NIV at PARDS diagnosis (NIV group). NIV failure rate (defined as tracheal intubation or death) was 84 of 160 patients (53%). Higher nonrespiratory pediatric logistic organ dysfunction (PELOD-2) score, PaO2/FIO2 was less than 100 at PARDS diagnosis, immunosuppression, and male sex were independently associated with NIV failure. NIV failure was 100% among patients with nonrespiratory PELOD-2 score greater than 2, PaO2/FIO2 less than 100, and immunosuppression all present. Among patients with PaO2/FIO2 greater than 100, children in the NIV group had shorter total duration of NIV and IMV, than the IMV at initial diagnosis group. We failed to identify associations between NIV use and PICU survival in a multivariable Cox regression analysis (hazard ratio 1.04 [95% CI, 0.61–1.80]) or mortality in a propensity score matched analysis (p = 0.369). CONCLUSIONS:: Use of NIV at PARDS diagnosis was associated with shorter exposure to IMV in children with mild to moderate hypoxemia. Even though risk of NIV failure was high in some children, we failed to identify greater hazard of mortality in these patients.