부산대학교 도서관

The antiobesity effects of kimchi with catechin and lactic acid bacteria as starters were studied in C57BL/6mice with high-fat diet (HFD)-induced obesity. We prepared four types of kimchi: commercial kimchi, standard kimchi, greentea functional kimchi, and catechin functional kimchi (CFK). Body weight and weight of adipose tissue were significantlylower in the kimchi-treated groups than in the HFD and Salt (HFD +1.5% NaCl) groups. In addition, in the CFK group, theserum levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol were significantly lower and thoseof high-density lipoprotein cholesterol were markedly higher than the corresponding levels in the HFD and Salt groups. Moreover, CFK reduced fat cells and crown-like structures in the liver and epididymal fat tissues. The protein expression ofadipo/lipogenesis-related genes in the liver and epididymal fat tissues was significantly lower (1.90–7.48-fold) in the CFKgroup than in the HFD and Salt groups, concurrent with upregulation of lipolysis-related genes (1.71–3.38-fold) and downregulationof inflammation-related genes (3.17–5.06-fold) in epididymal fat tissues. In addition, CFK modulated the gutmicrobiomes of obese mice by increasing the abundance of Bacteroidetes (7.61%), while in contrast, Firmicutes (82.21%)decreased. In addition, the presence of the Erysipelotrichaceae (8.37%) family in the CFK group decreased, while the numberof beneficial bacteria of the families, Akkermansiaceae (6.74%), Lachnospiraceae (14.95%), and Lactobacillaceae (38.41%),increased. Thus, CFK exhibited an antiobesity effect through its modulation of lipid metabolism and the microbiome.