부산대학교 도서관

Three cases of advanced maxillary sinus cancer with orbital invasion were treated with intra-arterial （IA） chemoradiation therapy including internal carotid arterial infusion to preserve ocular function. One case needed total maxillectomy with exenteration and two cases were inoperable. Two cases received alternating chemo-radiotherapy with two courses of intra-venous chemotherapy （TPF; taxotere, cisplatin, 5FU）. IA infusion of CDDP （35-50mg/m2/week） was administered through the microcatheter from the external carotid arterial sheath （ECAS） inserted into the superficial temporal artery. Total CDDP dose was 175-400mg/m2, and total CDDP dose to the internal carotid artery was 80-115mg/body. Intensity modulated radiation therapy （IMRT） was applied to three cases without exceeding the maximum dose to the optic nerve of more than 60Gy. Although the follow-up period was short, local control within the orbita and ocular functions were preserved in three cases. IA chemoradiation therapy including internal carotid arterial infusion might be useful to preserve ocular function.