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e-Article

EXPERIMENTAL STUDIES ON THE ECONOMICAL RINDERPEST VACCINE
Document Type
Journal Article
Source
Journal of The Japanese Society of Veterinary Science. 1927, 6(2):107
Subject
Language
English
ISSN
1883-9193
Abstract
1. Of the above described 17 organs collected from the animals infected with rinderpest, the thymus and tonsil have been found to have the most superior antigenic property and the lung was proved to rank next to the spleen in the antigenic power.2. It has been found that the minimum prophylactic dose of the lymphatic gland, thymus and tonsil is 0.15, 0.1 and 0.05 c.c. per kwan body weight respectively.3. Inoculation experiments showed that the combined vaccines No. 506 (lymphatic gland and tonsil) and No. 493 (thymus and tonsil) were more effective than those made from any one of the the organs mentioned, and especially the vaccine No. 493 was proved to be highly efficacious.4. Of various kinds of vaccines prepared by combining 2 or more of such organs, as spleen, lymphatic gland, thymus and tonsil, in various proportions, the one added with lung was found to be less efficacious than those lacking it, but was yet none of these vaccines the less efficacious as compared with those which have hitherto been made from the spleen.5. It is not yet determined which is superior as vaccine, No. 497 containing the spleen, lung, lymphatic gland, thymus and tonsil, and No, 493 prepared only from the thymus and tonsil, as further experiments are required regarding the preservation of them.It will be worthy of note that, by employing the combination method, the preparation of vaccine was highly improved, and the quantity of vaccine which can be prepared from one calf was amounted up to twice as much as before. For this reason we should like to designate the vaccine prepared by the combination method as "the economical rinderpest vaccine".