e-Article
Cryo-EM structure of the human MT1–Gi signaling complex / クライオ電子顕微鏡によるヒト由来メラトニン受容体シグナル伝達複合体の構造解析
Document Type
Journal Article
Author
Asuka Inoue; Hirokazu Tsujimoto; Hirotake Miyauchi; Keitaro Yamashita; Norimichi Nomura; Okamoto Hiroyuki; Osamu Nureki; Ryoji Suno; So Iwata; Takuya Kobayashi; Tomohiro Nishizawa; Tsukasa Kusakizako; Wataru Shihoya; 井上 飛鳥; 宮内 弘剛; 寿野 良二; 小林 拓也; 山下 恵太郎; 岡本 紘幸; 岩田 想; 志甫谷 渉; 濡木 理; 草木迫 司; 西澤 知宏; 辻本 浩一; 野村 紀通
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022, :1-54
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Recently reported crystal structures of ligand-bound MT1 and MT2 elucidated the structural basis of ligand entry and recognition, but the molecular mechanism of the ligand-induced MT1 structural change that would lead to Gi-coupling remains unclear.