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e-Article

Oral budesonide for active Crohn's disease
Document Type
Academic Journal
Source
The New England Journal of Medicine. Sept 29, 1994, Vol. v331 Issue n13, p836, 6 p.
Subject
Corticosteroids -- Evaluation
Crohn's disease -- Drug therapy
Language
ISSN
0028-4793
Abstract
Budesonide appears to be a safe and effective drug for treating Crohn's disease. Crohn's disease is an inflammatory bowel disease that may cause episodes of diarrhea, nausea, stomach pain, fever, or chills. Researchers studied 258 people with Crohn's disease, half of whom received budesonide in doses of three, nine, or 15 mg per day. After eight weeks of treatment, 51% of patients receiving 9 mg of budesonide and 43% of patients receiving 15 mg of budesonide had remission. Thirty-three patients who received 3 mg of budesonide experienced remission which was not significantly different from the remission rate in untreated patients. Patients who took budesonide in doses of 9 mg or 15 mg had greater improvements in their quality of life than untreated patients or those who took 3 mg of budesonide. Adverse symptoms were reported in a similar number of budesonide patients and untreated patients.