부산대학교 도서관

Alzheimer's disease (AD) is one of the major causes of chronic and progressive cognitive decline, with the pathological hallmarks of senile plaques and neurofibrillary tangles. Amyloid [beta] peptide (A[beta]) is the main component of senile plaques, and the pathological load of A[beta] in the brain has been shown to be a marker of the severity of AD. To prevent the accumulation of plaques, novel and safer plant-based vaccine strategies have been suggested. In this review, we summarize the results of plant vaccines against A[beta]. Keywords: amyloid [beta] protein, oral vaccine, plant-based vaccine, Alzheimer's disease
Introduction In Japan, Alzheimer's disease (AD) is the most common type of dementia, accounting for 63% of dementia cases (Fig. 1). The increase in the proportion of elderly people aged [...]