e-Article
Ubc9- and Mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks
Document Type
Report
Author
Source
Cell. Nov, 2006, Vol. 127 Issue 3, p509, 14 p.
Subject
Language
English
ISSN
0092-8674
Abstract
An attempt is made to propose that Ubc9 and Mms21 act in concert with Sgs1 to resolve the X structures formed during replication. The results have shown that Ubc9- and Mms21-mediated sumoylation functions as a regulatory mechanism, which is different from that of replication checkpoints, to prevent pathological accumulation of cruciform structures at damaged forks.