e-Article
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
Document Type
Academic Journal
Author
Source
Breast Cancer Research and Treatment. February 1, 2012, Vol. 131 Issue 3, p1003, 10 p.
Subject
Language
English
ISSN
0167-6806
Abstract
Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have seldom been studied in association with obesity. Gene expression profiles of normal breast tissue from reduction mammoplasty patients were evaluated by whole genome microarrays to identify patterns associated with obesity status (normal-weight, body mass index (BMI) Keywords Obesity * Breast * Inflammation * Gene expression * Macrophage infiltration
Introduction In past decades, the relationship between obesity and breast cancer risk has been extensively studied. It has been established that obesity is strongly associated with a higher risk of [...]
Introduction In past decades, the relationship between obesity and breast cancer risk has been extensively studied. It has been established that obesity is strongly associated with a higher risk of [...]