e-Article
MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells
Document Type
Report
Author
Source
Molecular Medicine Reports. June 2015, Vol. 11 Issue 6, p4567, 6 p.
Subject
Language
English
ISSN
1791-2997
Abstract
Introduction There are numerous types of B-cell lymphoma, including: Burkitt lymphoma, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma/mucosa-associated lymphoid tissue lymphoma, nodal [...]
The function of microRNAs (miRNAs) in tumori genesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR-204 in B-cell lymphoma. The present study demonstrated that miR-204 is downregulated in B-cell lymphoma. Using in vitro studies, overexpression of miR-204 was shown to inhibit growth in Daudi and Raji B-cell lymphoma cell lines. Furthermore, miR-204 could bind the 3'-untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes B-cell lymphoma oncogenesis. Re-introduction of STAT5 reversed the antiproliferative roles of miR-204, confirming the specific importance of STAT5 for miR-204 action in cell proliferation. The present study suggests a novel mechanism for dysregulated miRNAs in the progression of B-cell lymphoma. Key words: microRNA-204, signal transducer and activator of transcription 5, B-cell lymphoma, proliferation
The function of microRNAs (miRNAs) in tumori genesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR-204 in B-cell lymphoma. The present study demonstrated that miR-204 is downregulated in B-cell lymphoma. Using in vitro studies, overexpression of miR-204 was shown to inhibit growth in Daudi and Raji B-cell lymphoma cell lines. Furthermore, miR-204 could bind the 3'-untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes B-cell lymphoma oncogenesis. Re-introduction of STAT5 reversed the antiproliferative roles of miR-204, confirming the specific importance of STAT5 for miR-204 action in cell proliferation. The present study suggests a novel mechanism for dysregulated miRNAs in the progression of B-cell lymphoma. Key words: microRNA-204, signal transducer and activator of transcription 5, B-cell lymphoma, proliferation