e-Article
Genomic structure and chromosomal localization of the human deoxycytidine kinase gene
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. Jan 15, 1993, Vol. 90 Issue 2, p431, 4 p.
Subject
Language
ISSN
0027-8424
Abstract
Deoxycytidine (dCyd) kinase is responsible for phosphorylating deoxyribonuclesides and nucleoside analogs, andhas a potential role in mediating tissue-specific cytotoxicity of chemotherapeutic agents. The gene coding for human dCyd kinase was characterized. The gene was localized to chromosome 4 and spanned over 34 kilobases. It is composed of seven exons and is expressed predominantly in thymocytes and leukemic T lymphoblasts. Further characterization of the 5' region showed the presence of potential regulatory sites which may be importantfor tissue-specific patterns of dCyd kinase expression.