부산대학교 도서관

Background/Aim: Breast angiosarcoma is a rare and aggressive disease with a poor prognosis. Two subtypes have been identified: primary angiosarcoma (PBA) and secondary breast angiosarcoma (SBA). In this retrospective analysis, we describe and compare our institute experience with the data existing in the literature. Materials and Methods: We included in our analysis 29 patients who received a diagnosis of PBA or SBA between 2006 and 2019. Results: All patients received surgery as frontline treatment, but only 6 patients underwent to adjuvant treatment. Neoadjuvant chemotherapy was administered 2 patients. The preferred chemotherapeutic regimen was taxanes with or without gemcitabine and associated with anthracyclines. A lower median RFS and OS were reported in patients with PBA compared to those with SBA, but the difference observed was not statistically significant. Patients with PBA had a lower median age at the diagnosis (38 vs. 75). Conclusion: In our analysis, we have shown a lower median RFS and OS in patients with PBA compared with those with SBA, and a significantly younger age at diagnosis in patients affected by PBA. Keywords: Soft tissue sarcoma, Breast angiosarcoma, Endothelial markers, Anthracyclines
Author(s): Lucia Cannella [a]; Francesco Perri [b]; Ottavia Clemente [a]; Claudia von Arx [c]; Antonio Pizzolorusso [a]; Maurizio Di Bonito [d]; Alessandra Bracigliano [e]; Massimiliano Di Marzo [f]; Giuseppina Della [...]