부산대학교 도서관

In this study, we determined the inhibitory activity of P. rhoeas against particulate matter-induced cell death, ROS production, and collagen degradation. First, the cytotoxicity of P. rhoeas extract was determined. The cytotoxicity was measured using HEKa and CCD-986sk. The cytotoxicity did not show cytotoxicity in the range of 12.5-200 μg/mL. HEKa was used to measure the inhibitory effect of P. rhoeas on PM2.5 and PM10-induced cell death. It was found that P. rhoeas extract inhibited PM2.5, PM10 (PAHs), and PM10 (metals)-induced cell death. CCD-986sk was used to measure the effect of ROS inhibition by particulate matter. It was found that P. rhoeas extract reduce particulate matter-induced ROS. CCD-986sk was used to measure the effect of inhibiting collagen degradation by particulate matter. It was found that P. rhoeas extract reduce particulate matter-induced collagen degradation. In all the studies in this study, PM10 (metal) had the least negative effect, while PM2.5 had the most negative effect. At the same time, when P. rhoeas extract was treated, the negative effects induced by PM10 were reduced to a level similar to the control, while PM2.5 showed a relatively low improvement rate.