e-Article
SARS-CoV-2 Infection Caused a Damage on Vascular Bed Co-Cultured with Bronchial Organoids in Microfluidic Device
Document Type
Conference
Author
Source
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) Solid-State Sensors, Actuators and Microsystems (Transducers), 2023 22nd International Conference on. :1066-1069 Jun, 2023
Subject
Language
ISSN
2167-0021
Abstract
This paper reports the effect of SARS-CoV-2 infection on bronchial organoids and endothelial vasculature formed with human primary cells in microfluidic devices. Established model enables us to analyze virus infection site and interaction on multiple type of cells, showing infection tropism to bronchial organoids and vasculature damages. Further analysis revealed that vascular structure was damaged through paracrine pathway caused by cytokines released from infected bronchial organoids. These results demonstrated that proposing model is capable to evaluate complex mechanism of vascular symptoms in COVID-19 and comparison of pathogenicity between multiple strains.