e-Article
Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
Document Type
article
Author
Josephine M. Forbes; Selena Le Bagge; Samuel Righi; Amelia K. Fotheringham; Linda A. Gallo; Domenica A. McCarthy; Sherman Leung; Tracey Baskerville; Janelle Nisbett; Adam Morton; Stephanie Teasdale; Neisha D’Silva; Helen Barrett; Timothy Jones; Jennifer Couper; Kim Donaghue; Nicole Isbel; David W. Johnson; Leigh Donnellan; Permal Deo; Lisa K. Akison; Karen M. Moritz; Trisha O’Moore-Sullivan
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFRCKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model