e-Article
Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
Document Type
article
Author
Rajkumar Dorajoo; Xuling Chang; Resham Lal Gurung; Zheng Li; Ling Wang; Renwei Wang; Kenneth B. Beckman; Jennifer Adams-Haduch; Yiamunaa M; Sylvia Liu; Wee Yang Meah; Kar Seng Sim; Su Chi Lim; Yechiel Friedlander; Jianjun Liu; Rob M. van Dam; Jian-Min Yuan; Woon-Puay Koh; Chiea Chuen Khor; Chew-Kiat Heng
Source
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Shortening of leukocyte telomere length (LTL) is associated with age and increased risk for various chronic diseases. Here, the authors report genome-wide association studies for LTL in Singaporean Chinese populations and find that longer LTL associates with less severe outcomes of respiratory disease phenotypes.