e-Article
Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19
Document Type
article
Author
Ashwin Sunderraj, BS; Chloe Cho; Xuan Cai, MS; Shruti Gupta, MD, MPH; Rupal Mehta, MD, MSCI; Tamara Isakova, MD, MMSc; David E. Leaf, MD, MMSc; Anand Srivastava, MD, MPH; STOP-COVID Investigators; Carl P. Walther; Samaya J. Anumudu; Justin Arunthamakun; Kathleen F. Kopecky; Gregory P. Milligan; Peter A. McCullough; Thuy-Duyen Nguyen; Shahzad Shaefi; Megan L. Krajewski; Sidharth Shankar; Ameeka Pannu; Juan D. Valencia; Sushrut S. Waikar; Zoe A. Kibbelaar; Ambarish M. Athavale; Peter Hart; Shristi Upadhyay; Ishaan Vohra; Ajiboye Oyintayo; Adam Green; Jean-Sebastien Rachoin; Christa A. Schorr; Lisa Shea; Daniel L. Edmonston; Christopher L. Mosher; Alexandre M. Shehata; Zaza Cohen; Valerie Allusson; Gabriela Bambrick-Santoyo; Noor ul aain Bhatti; Bijal Mehta; Aquino Williams; Samantha K. Brenner; Patricia Walters; Ronaldo C. Go; Keith M. Rose; Miguel A. Hernán; Amy M. Zhou; Ethan C. Kim; Rebecca Lisk; Lili Chan; Kusum S. Mathews; Steven G. Coca; Deena R. Altman; Aparna Saha; Howard Soh; Huei Hsun Wen; Sonali Bose; Emily A. Leven; Jing G. Wang; Gohar Mosoyan; Girish N. Nadkarni; Pattharawin Pattharanitima; Emily J. Gallagher; Allon N. Friedman; John Guirguis; Rajat Kapoor; Christopher Meshberger; Katherine J. Kelly; Chirag R. Parikh; Brian T. Garibaldi; Celia P. Corona-Villalobos; Yumeng Wen; Steven Menez; Rubab F. Malik; Carmen Elena Cervantes; Samir C. Gautam; Mary C. Mallappallil; Jie Ouyang; Sabu John; Ernie Yap; Yohannes Melaku; Ibrahim Mohamed; Siddhartha Bajracharya; Isha Puri; Mariah Thaxton; Jyotsna Bhattacharya; John Wagner; Leon Boudourakis; H. Bryant Nguyen; Afshin Ahoubim; Leslie F. Thomas; Dheeraj Reddy Sirganagari; Pramod K. Guru; Kianoush Kashani; Shahrzad Tehranian; Yan Zhou; Paul A. Bergl; Jesus Rodriguez; Jatan A. Shah; Mrigank S. Gupta; Princy N. Kumar; Deepa G. Lazarous; Seble G. Kassaye; Michal L. Melamed; Tanya S. Johns; Ryan Mocerino; Kalyan Prudhvi; Denzel Zhu; Rebecca V. Levy; Yorg Azzi; Molly Fisher; Milagros Yunes; Kaltrina Sedaliu; Ladan Golestaneh; Maureen Brogan; Neelja Kumar; Michael Chang; Jyotsana Thakkar; Ritesh Raichoudhury; Akshay Athreya; Mohamed Farag; Edward J. Schenck; Soo Jung Cho; Maria Plataki; Sergio L. Alvarez-Mulett; Luis G. Gomez-Escobar; Di Pan; Stefi Lee; Jamuna Krishnan; William Whalen; David Charytan; Ashley Macina; Sobaata Chaudhry; Benjamin Wu; Frank Modersitzki; Anand Srivastava; Alexander S. Leidner; Carlos Martinez; Jacqueline M. Kruser; Richard G. Wunderink; Alexander J. Hodakowski; Juan Carlos Q. Velez; Eboni G. Price-Haywood; Luis A. Matute-Trochez; Anna E. Hasty; Muner MB. Mohamed; Rupali S. Avasare; David Zonies; David E. Leaf; Shruti Gupta; Meghan E. Sise; Erik T. Newman; Samah Abu Omar; Kapil K. Pokharel; Shreyak Sharma; Harkarandeep Singh; Simon Correa; Tanveer Shaukat; Omer Kamal; Wei Wang; Heather Yang; Jeffery O. Boateng; Meghan Lee; Ian A. Strohbehn; Jiahua Li; Ariel L. Mueller; Roberta E. Redfern; Nicholas S. Cairl; Gabriel Naimy; Abeer Abu-Saif; Danyell Hall; Laura Bickley; Chris Rowan; Farah Madhani-Lovely; Vivian S. Cruz; Kristen M. Hess; Alanna L. Jacobs; Vasil Peev; Jochen Reiser; John J. Byun; Andrew Vissing; Esha M. Kapania; Zoe Post; Nilam P. Patel; Joy-Marie Hermes; Anne K. Sutherland; Amee Patrawalla; Diana G. Finkel; Barbara A. Danek; Sowminya Arikapudi; Jeffrey M. Paer; Peter Cangialosi; Mark Liotta; Jared Radbel; Sonika Puri; Jag Sunderram; Matthew T. Scharf; Ayesha Ahmed; Ilya Berim; Jayanth S. Vatson; Shuchi Anand; Joseph E. Levitt; Pablo Garcia; Suzanne M. Boyle; Rui Song; Jingjing Zhang; Sang Hoon Woo; Xiaoying Deng; Goni Katz-Greenberg; Katharine Senter; Moh’d A. Sharshir; Vadym V. Rusnak; Muhammad Imran Ali; Anip Bansal; Amber S. Podoll; Michel Chonchol; Sunita Sharma; Ellen L. Burnham; David J. Douin; Arash Rashidi; Rana Hejal; Eric Judd; Laura Latta; Ashita Tolwani; Timothy E. Albertson; Jason Y. Adams; Steven Y. Chang; Rebecca M. Beutler; Carl E. Schulze; Etienne Macedo; Harin Rhee; Kathleen D. Liu; Vasantha K. Jotwani; Jay L. Koyner; Chintan V. Shah; Vishal Jaikaransingh; Stephanie M. Toth-Manikowski; Min J. Joo; James P. Lash; Javier A. Neyra; Nourhan Chaaban; Madona Elias; Yahya Ahmad; Alfredo Iardino; Elizabeth H. Au; Jill H. Sharma; Marie Anne Sosa; Sabrina Taldone; Gabriel Contreras; David De La Zerda; Hayley B. Gershengorn; Bhavarth Shukla; Alessia Fornoni; Tanira Ferreira; Salim S. Hayek; Pennelope Blakely; Hanna Berlin; Tariq U. Azam; Husam Shadid; Michael Pan; Patrick O’ Hayer; Chelsea Meloche; Rafey Feroze; Rayan Kaakati; Danny Perry; Abbas Bitar; Elizabeth Anderson; Kishan J. Padalia; John P. Donnelly; Andrew J. Admon; Jennifer E. Flythe; Matthew J. Tugman; Emily H. Chang; Brent R. Brown; Amanda K. Leonberg-Yoo; Ryan C. Spiardi; Todd A. Miano; Meaghan S. Roche; Charles R. Vasquez; Amar D. Bansal; Natalie C. Ernecoff; Sanjana Kapoor; Siddharth Verma; Huiwen Chen; Csaba P. Kovesdy; Miklos Z. Molnar; Ambreen Azhar; S. Susan Hedayati; Mridula V. Nadamuni; Shani Shastri; Duwayne L. Willett; Samuel A.P. Short; Amanda D. Renaghan; Kyle B. Enfield; Pavan K. Bhatraju; A. Bilal Malik; Matthew W. Semler; Anitha Vijayan; Christina Mariyam Joy; Tingting Li; Seth Goldberg; Patricia F. Kao; Greg L. Schumaker; Nitender Goyal; Anthony J. Faugno; Caroline M. Hsu; Asma Tariq; Leah Meyer; Ravi K. Kshirsagar; Daniel E. Weiner; Aju Jose; Marta Christov; Jennifer Griffiths; Sanjeev Gupta; Aromma Kapoor; Perry Wilson; Tanima Arora; Ugochukwu Ugwuowo
Source
Critical Care Explorations, Vol 4, Iss 9, p e0755 (2022)
Subject
Language
English
ISSN
2639-8028
00000000
91604508
00000000
91604508
Abstract
OBJECTIVES:. Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between age and death. DESIGN:. Multicenter cohort study. SETTING:. ICUs at 68 hospitals across the United States. PATIENTS:. A total of 5,037 critically ill adults with COVID-19 admitted to ICUs between March 1, 2020, and July 1, 2020. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. The primary exposure was age, modeled as a continuous variable. The primary outcome was 28-day inhospital mortality. Multivariable logistic regression tested the association between age and death. Effect modification by the number of risk factors was assessed through a multiplicative interaction term in the logistic regression model. Among the 5,037 patients included (mean age, 60.9 yr [± 14.7], 3,179 [63.1%] male), 1,786 (35.4%) died within 28 days. Age had a nonlinear association with 28-day mortality (p for nonlinearity