e-Article
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
Document Type
article
Author
Mariya Misheva; Konstantinos Kotzamanis; Luke C. Davies; Victoria J. Tyrrell; Patricia R. S. Rodrigues; Gloria A. Benavides; Christine Hinz; Robert C. Murphy; Paul Kennedy; Philip R. Taylor; Marcela Rosas; Simon A. Jones; James E. McLaren; Sumukh Deshpande; Robert Andrews; Nils Helge Schebb; Magdalena A. Czubala; Mark Gurney; Maceler Aldrovandi; Sven W. Meckelmann; Peter Ghazal; Victor Darley-Usmar; Daniel A. White; Valerie B. O’Donnell
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a mitochondria lipid importer protein, to serve as a metabolic checkpoint for oxylipin homeostasis and inflammation.