e-Article
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
Document Type
article
Author
Joshua C Randall; Thomas W Winkler; Zoltán Kutalik; Sonja I Berndt; Anne U Jackson; Keri L Monda; Tuomas O Kilpeläinen; Tõnu Esko; Reedik Mägi; Shengxu Li; Tsegaselassie Workalemahu; Mary F Feitosa; Damien C Croteau-Chonka; Felix R Day; Tove Fall; Teresa Ferreira; Stefan Gustafsson; Adam E Locke; Iain Mathieson; Andre Scherag; Sailaja Vedantam; Andrew R Wood; Liming Liang; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Emmanouil T Dermitzakis; Antigone S Dimas; Fredrik Karpe; Josine L Min; George Nicholson; Deborah J Clegg; Thomas Person; Jon P Krohn; Sabrina Bauer; Christa Buechler; Kristina Eisinger; DIAGRAM Consortium; Amélie Bonnefond; Philippe Froguel; MAGIC Investigators; Jouke-Jan Hottenga; Inga Prokopenko; Lindsay L Waite; Tamara B Harris; Albert Vernon Smith; Alan R Shuldiner; Wendy L McArdle; Mark J Caulfield; Patricia B Munroe; Henrik Grönberg; Yii-Der Ida Chen; Guo Li; Jacques S Beckmann; Toby Johnson; Unnur Thorsteinsdottir; Maris Teder-Laving; Kay-Tee Khaw; Nicholas J Wareham; Jing Hua Zhao; Najaf Amin; Ben A Oostra; Aldi T Kraja; Michael A Province; L Adrienne Cupples; Nancy L Heard-Costa; Jaakko Kaprio; Samuli Ripatti; Ida Surakka; Francis S Collins; Jouko Saramies; Jaakko Tuomilehto; Antti Jula; Veikko Salomaa; Jeanette Erdmann; Christian Hengstenberg; Christina Loley; Heribert Schunkert; Claudia Lamina; H Erich Wichmann; Eva Albrecht; Christian Gieger; Andrew A Hicks; Asa Johansson; Peter P Pramstaller; Sekar Kathiresan; Elizabeth K Speliotes; Brenda Penninx; Anna-Liisa Hartikainen; Marjo-Riitta Jarvelin; Ulf Gyllensten; Dorret I Boomsma; Harry Campbell; James F Wilson; Stephen J Chanock; Martin Farrall; Anuj Goel; Carolina Medina-Gomez; Fernando Rivadeneira; Karol Estrada; André G Uitterlinden; Albert Hofman; M Carola Zillikens; Martin den Heijer; Lambertus A Kiemeney; Andrea Maschio; Per Hall; Jonathan Tyrer; Alexander Teumer; Henry Völzke; Peter Kovacs; Anke Tönjes; Massimo Mangino; Tim D Spector; Caroline Hayward; Igor Rudan; Alistair S Hall; Nilesh J Samani; Antony Paul Attwood; Jennifer G Sambrook; Joseph Hung; Lyle J Palmer; Marja-Liisa Lokki; Juha Sinisalo; Gabrielle Boucher; Heikki Huikuri; Mattias Lorentzon; Claes Ohlsson; Niina Eklund; Johan G Eriksson; Cristina Barlassina; Carlo Rivolta; Ilja M Nolte; Harold Snieder; Melanie M Van der Klauw; Jana V Van Vliet-Ostaptchouk; Pablo V Gejman; Jianxin Shi; Kevin B Jacobs; Zhaoming Wang; Stephan J L Bakker; Irene Mateo Leach; Gerjan Navis; Pim van der Harst; Nicholas G Martin; Sarah E Medland; Grant W Montgomery; Jian Yang; Daniel I Chasman; Paul M Ridker; Lynda M Rose; Terho Lehtimäki; Olli Raitakari; Devin Absher; Carlos Iribarren; Hanneke Basart; Kees G Hovingh; Elina Hyppönen; Chris Power; Denise Anderson; John P Beilby; Jennie Hui; Jennifer Jolley; Hendrik Sager; Stefan R Bornstein; Peter E H Schwarz; Kati Kristiansson; Markus Perola; Jaana Lindström; Amy J Swift; Matti Uusitupa; Mustafa Atalay; Timo A Lakka; Rainer Rauramaa; Jennifer L Bolton; Gerry Fowkes; Ross M Fraser; Jackie F Price; Krista Fischer; Kaarel Krjutå Kov; Andres Metspalu; Evelin Mihailov; Claudia Langenberg; Jian'an Luan; Ken K Ong; Peter S Chines; Sirkka M Keinanen-Kiukaanniemi; Timo E Saaristo; Sarah Edkins; Paul W Franks; Göran Hallmans; Dmitry Shungin; Andrew David Morris; Colin N A Palmer; Raimund Erbel; Susanne Moebus; Markus M Nöthen; Sonali Pechlivanis; Kristian Hveem; Narisu Narisu; Anders Hamsten; Steve E Humphries; Rona J Strawbridge; Elena Tremoli; Harald Grallert; Barbara Thorand; Thomas Illig; Wolfgang Koenig; Martina Müller-Nurasyid; Annette Peters; Bernhard O Boehm; Marcus E Kleber; Winfried März; Bernhard R Winkelmann; Johanna Kuusisto; Markku Laakso; Dominique Arveiler; Giancarlo Cesana; Kari Kuulasmaa; Jarmo Virtamo; John W G Yarnell; Diana Kuh; Andrew Wong; Lars Lind; Ulf de Faire; Bruna Gigante; Patrik K E Magnusson; Nancy L Pedersen; George Dedoussis; Maria Dimitriou; Genovefa Kolovou; Stavroula Kanoni; Kathleen Stirrups; Lori L Bonnycastle; Inger Njølstad; Tom Wilsgaard; Andrea Ganna; Emil Rehnberg; Aroon Hingorani; Mika Kivimaki; Meena Kumari; Themistocles L Assimes; Inês Barroso; Michael Boehnke; Ingrid B Borecki; Panos Deloukas; Caroline S Fox; Timothy Frayling; Leif C Groop; Talin Haritunians; David Hunter; Erik Ingelsson; Robert Kaplan; Karen L Mohlke; Jeffrey R O'Connell; David Schlessinger; David P Strachan; Kari Stefansson; Cornelia M van Duijn; Gonçalo R Abecasis; Mark I McCarthy; Joel N Hirschhorn; Lu Qi; Ruth J F Loos; Cecilia M Lindgren; Kari E North; Iris M Heid
Source
PLoS Genetics, Vol 9, Iss 6, p e1003500 (2013)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR