e-Article
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis
Document Type
article
Author
Matthias Merker; Jean-Philippe Rasigade; Maxime Barbier; Helen Cox; Silke Feuerriegel; Thomas A. Kohl; Egor Shitikov; Kadri Klaos; Cyril Gaudin; Rudy Antoine; Roland Diel; Sonia Borrell; Sebastien Gagneux; Vladyslav Nikolayevskyy; Sönke Andres; Valeriu Crudu; Philip Supply; Stefan Niemann; Thierry Wirth
Source
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
An outbreak of the multidrug-resistant Mycobacterium tuberculosis lineage W148 has spread widely across Russia, Central Asia and Europe. Here, the authors use whole genome sequences of ~700 isolates of this lineage collected over ~20 years to analyze its spread, evolution of drug resistance, and impact of compensatory mutations.