e-Article
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
Document Type
article
Author
Lisa Hurler; Ágnes Szilágyi; Federica Mescia; Laura Bergamaschi; Blanka Mező; György Sinkovits; Marienn Réti; Veronika Müller; Zsolt Iványi; János Gál; László Gopcsa; Péter Reményi; Beáta Szathmáry; Botond Lakatos; János Szlávik; Ilona Bobek; Zita Z. Prohászka; Zsolt Förhécz; Dorottya Csuka; Erika Kajdácsi; László Cervenak; Petra Kiszel; Tamás Masszi; István Vályi-Nagy; Reinhard Würzner; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Paul A. Lyons; Erik J. M. Toonen; Zoltán Prohászka; Stephen Baker; John R. Bradley; Patrick F. Chinnery; Daniel J. Cooper; Gordon Dougan; Ian G. Goodfellow; Ravindra K. Gupta; Nathalie Kingston; Paul J. Lehner; Nicholas J. Matheson; Caroline Saunders; Kenneth G. C. Smith; Charlotte Summers; James Thaventhiran; M. Estee Torok; Mark R. Toshner; Michael P. Weekes; Gisele Alvio; Sharon Baker; Areti Bermperi; Karen Brookes; Ashlea Bucke; Jo Calder; Laura Canna; Cherry Crucusio; Isabel Cruz; Rnalie de Jesus; Katie Dempsey; Giovanni Di Stephano; Jason Domingo; Anne Elmer; Julie Harris; Sarah Hewitt; Heather Jones; Sherly Jose; Jane Kennet; Yvonne King; Jenny Kourampa; Emily Li; Caroline McMahon; Anne Meadows; Vivien Mendoza; Criona O’Brien; Charmain Ocaya; Ciro Pascuale; Marlyn Perales; Jane Price; Rebecca Rastall; Carla Ribeiro; Jane Rowlands; Valentina Ruffolo; Hugo Tordesillas; Phoebe Vargas; Bensi Vergese; Laura Watson; Jieniean Worsley; Julie-Ann Zerrudo; Ariana Betancourt; Georgie Bower; Ben Bullman; Chiara Cossetti; Aloka De Sa; Benjamin J. Dunore; Maddie Epping; Stuart Fawke; Stefan Gräf; Richard Grenfell; Andrew Hinch; Josh Hodgson; Christopher Huang; Oisin Huhn; Kelvin Hunter; Isobel Jarvis; Emma Jones; Maša Josipović; Ekaterina Legchenko; Daniel Lewis; Joe Marsden; Jennifer Martin; Francesca Nice; Ciara O’Donnell; Ommar Omarjee; Marianne Perera; Linda Pointon; Nicole Pond; Nathan Richoz; Nika Romashova; Natalia Savoinykh; Rahul Sharma; Joy Shih; Mateusz Strezlecki; Rachel Sutcliffe; Tobias Tilly; Zhen Tong; Carmen Treacy; Lori Turner; Jennifer Wood; Marta Wylot; John Allison; Heather Biggs; Helen Butcher; Daniela Caputo; Debbie Clapham-Riley; Eleanor Dewhurst; Christian Fernandez; Anita Furlong; Barbara Graves; Jennifer Gray; Tasmin Ivers; Emma Le Gresley; Rachel Linger; Mary Kasanicki; Sarah Meloy; Francesca Muldoon; Nigel Ovington; Sofia Papadia; Christopher J. Penkett; Isabel Phelan; Venkatesh Ranganath; Jennifer Sambrook; Katherine Schon; Hannah Stark; Kathleen E. Stirrups; Paul Townsend; Julie von Ziegenweidt; Jennifer Webster; Ali Asaripour; Lucy Mwaura; Caroline Patterson; Gary Polwarth; Katherine Bunclark; Michael Mackay; Alice Michael; Sabrina Rossi; Mayurun Selvan; Sarah Spencer; Cissy Yong; Petra Polgarova
Source
Frontiers in Immunology, Vol 14 (2023)
Subject
Language
English
ISSN
1664-3224
Abstract
IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin pathway activation and its key pattern recognition molecule MBL in COVID-19 is still not fully understood.MethodsWe therefore investigated activation of the lectin pathway in two independent cohorts of SARS-CoV-2 infected patients, while also analysing MBL protein levels and potential effects of the six major single nucleotide polymorphisms (SNPs) found in the MBL2 gene on COVID-19 severity and outcome.ResultsWe show that the lectin pathway is activated in acute COVID-19, indicated by the correlation between complement activation product levels of the MASP-1/C1-INH complex (p=0.0011) and C4d (p