e-Article
The Multifaceted S100B Protein: A Role in Obesity and Diabetes?
Document Type
article
Author
Source
International Journal of Molecular Sciences, Vol 25, Iss 2, p 776 (2024)
Subject
Language
English
ISSN
1422-0067
1661-6596
1661-6596
Abstract
The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.