e-Article
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
Document Type
article
Author
Bjoern Meyer; Jeanne Chiaravalli; Stacy Gellenoncourt; Philip Brownridge; Dominic P. Bryne; Leonard A. Daly; Arturas Grauslys; Marius Walter; Fabrice Agou; Lisa A. Chakrabarti; Charles S. Craik; Claire E. Eyers; Patrick A. Eyers; Yann Gambin; Andrew R. Jones; Emma Sierecki; Eric Verdin; Marco Vignuzzi; Edward Emmott
Source
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass spectrometry to characterize the proteolytic cleavage profile of viral and cellular proteins in vitro.