e-Article
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
Document Type
article
Author
Suhasini Joshi; Erica DaGama Gomes; Tai Wang; Adriana Corben; Tony Taldone; Srinivasa Gandu; Chao Xu; Sahil Sharma; Salma Buddaseth; Pengrong Yan; Lon Yin L. Chan; Askan Gokce; Vinagolu K. Rajasekhar; Lisa Shrestha; Palak Panchal; Justina Almodovar; Chander S. Digwal; Anna Rodina; Swathi Merugu; NagaVaraKishore Pillarsetty; Vlad Miclea; Radu I. Peter; Wanyan Wang; Stephen D. Ginsberg; Laura Tang; Marissa Mattar; Elisa de Stanchina; Kenneth H. Yu; Maeve Lowery; Olivera Grbovic-Huezo; Eileen M. O’Reilly; Yelena Janjigian; John H. Healey; William R. Jarnagin; Peter J. Allen; Chris Sander; Hediye Erdjument-Bromage; Thomas A. Neubert; Steven D. Leach; Gabriela Chiosis
Source
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this, the authors employ chemical modulation of the interactome via epichaperome inhibition with the small molecule PU-H71.