e-Article
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
Document Type
article
Author
Teresa Lambe; Alexandra J. Spencer; Kelly M. Thomas; Karen E. Gooch; Stephen Thomas; Andrew D. White; Holly E. Humphries; Daniel Wright; Sandra Belij-Rammerstorfer; Nazia Thakur; Carina Conceicao; Robert Watson; Leonie Alden; Lauren Allen; Marilyn Aram; Kevin R. Bewley; Emily Brunt; Phillip Brown; Breeze E. Cavell; Rebecca Cobb; Susan A. Fotheringham; Ciaran Gilbride; Debbie J. Harris; Catherine M. K. Ho; Laura Hunter; Chelsea L. Kennard; Stephanie Leung; Vanessa Lucas; Didier Ngabo; Kathryn A. Ryan; Hannah Sharpe; Charlotte Sarfas; Laura Sibley; Gillian S. Slack; Marta Ulaszewska; Nadina Wand; Nathan R. Wiblin; Fergus V. Gleeson; Dalan Bailey; Sally Sharpe; Sue Charlton; Francisco J. Salguero; Miles W. Carroll; Sarah C. Gilbert
Source
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.