e-Article
Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype
Document Type
article
Author
Markus Rotter; Stefan Brandmaier; Marcela Covic; Katarzyna Burek; Johannes Hertel; Martina Troll; Erik Bader; Jonathan Adam; Cornelia Prehn; Birgit Rathkolb; Martin Hrabe de Angelis; Hans Jörgen Grabe; Hannelore Daniel; Thomas Kantermann; Volker Harth; Thomas Illig; Dirk Pallapies; Thomas Behrens; Thomas Brüning; Jerzy Adamski; Heiko Lickert; Sylvia Rabstein; Rui Wang-Sattler
Source
Metabolites, Vol 8, Iss 3, p 45 (2018)
Subject
Language
English
ISSN
2218-1989
Abstract
Night shift work can have a serious impact on health. Here, we assess whether and how night shift work influences the metabolite profiles, specifically with respect to different chronotype classes. We have recruited 100 women including 68 nurses working both, day shift and night shifts for up to 5 consecutive days and collected 3640 spontaneous urine samples. About 424 waking-up urine samples were measured using a targeted metabolomics approach. To account for urine dilution, we applied three methods to normalize the metabolite values: creatinine-, osmolality- and regression-based normalization. Based on linear mixed effect models, we found 31 metabolites significantly (false discovery rate