e-Article
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Document Type
article
Author
Peitao Wu; Denis Rybin; Lawrence F Bielak; Mary F Feitosa; Nora Franceschini; Yize Li; Yingchang Lu; Jonathan Marten; Solomon K Musani; Raymond Noordam; Sridharan Raghavan; Lynda M Rose; Karen Schwander; Albert V Smith; Salman M Tajuddin; Dina Vojinovic; Najaf Amin; Donna K Arnett; Erwin P Bottinger; Ayse Demirkan; Jose C Florez; Mohsen Ghanbari; Tamara B Harris; Lenore J Launer; Jingmin Liu; Jun Liu; Dennis O Mook-Kanamori; Alison D Murray; Mike A Nalls; Patricia A Peyser; André G Uitterlinden; Trudy Voortman; Claude Bouchard; Daniel Chasman; Adolfo Correa; Renée de Mutsert; Michele K Evans; Vilmundur Gudnason; Caroline Hayward; Linda Kao; Sharon L R Kardia; Charles Kooperberg; Ruth J F Loos; Michael M Province; Tuomo Rankinen; Susan Redline; Paul M Ridker; Jerome I Rotter; David Siscovick; Blair H Smith; Cornelia van Duijn; Alan B Zonderman; D C Rao; James G Wilson; Josée Dupuis; James B Meigs; Ching-Ti Liu; Jason L Vassy
Source
PLoS ONE, Vol 15, Iss 5, p e0230815 (2020)
Subject
Language
English
ISSN
1932-6203
Abstract
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies from the Cohorts for Heart Aging Research in Genomic Epidemiology Consortium (n = 74,584). In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p