e-Article
Neurological Disorders in Takotsubo Syndrome: Clinical Phenotypes and Outcomes
Document Type
article
Author
Francesco Santoro; Iván J. Núñez Gil; Luca Arcari; Enrica Vitale; Tommaso Martino; Ibrahim El‐Battrawy; Federico Guerra; Giuseppina Novo; Enrica Mariano; Beatrice Musumeci; Luca Cacciotti; Pasquale Caldarola; Roberta Montisci; Ilaria Ragnatela; Rosa Cetera; Oscar Vedia; Emilia Blanco; Javier Lopez Pais; Agustin Martin; Alberto Pérez‐Castellanos; Jorge Salamanca; Francesco Bartolomucci; Ibrahim Akin; Holger Thiele; Ingo Eitel; Thomas Stiermaier; Natale Daniele Brunetti
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)
Subject
Language
English
ISSN
2047-9980
Abstract
Background Neurological disorders as a risk factor for Takotsubo syndrome (TTS) are not well characterized. The aim of the study was to evaluate TTS‐associated neurological phenotypes and outcome. Methods and Results Patients with TTS enrolled in the international multicenter GEIST (German Italian Spanish Takotsubo) registry were analyzed. Prevalence, clinical characteristics, and short‐ and long‐term outcomes of patients with TTS were recorded. A subgroup analysis of the 5 most represented neurological disorders was performed. In total, 400 (17%) of 2301 patients had neurological disorders. The most represented neurological conditions were previous cerebrovascular events (39%), followed by neurodegenerative disorders (30.7%), migraine (10%), epilepsy (9.5%), and brain tumors (5%). During hospitalization, patients with neurological disorders had longer in‐hospital stay (8 [interquartile range, 5–12] versus 6 [interquartile range, 5–9] days; P