KOR

e-Article

Ovarian Cancer Radiosensitivity: What Have We Understood So Far?
Document Type
article
Source
Life, Vol 13, Iss 1, p 6 (2022)
Subject
ovarian cancer
radiobiology
radioresistance
radiosensitivity
radiation
Science
Language
English
ISSN
2075-1729
Abstract
Radiotherapy has been increasingly considered as an active treatment to combine with other approaches (i.e., surgery, chemotherapy, and novel target-based drugs) in ovarian cancers to palliate symptoms and/or to prolong chemotherapy-free intervals. This narrative review aimed to summarize the current knowledge of the radiosensitivity/radioresistance of ovarian cancer which remains the most lethal gynecological cancer worldwide. Indeed, considering the high rate of recurrence in and out of the radiotherapy fields, in the era of patient-tailored oncology, elucidating the mechanisms of radiosensitivity and identifying potential radioresistance biomarkers could be crucial in guiding clinical decision-making.