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e-Article

Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
Document Type
article
Source
Medical Mycology Case Reports, Vol 19, Iss C, Pp 18-20 (2018)
Subject
Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
Medicine (General)
R5-920
Biology (General)
QH301-705.5
Language
English
ISSN
2211-7539
Abstract
We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months