e-Article
Discovery of a Novel Human Pegivirus in Blood Associated with Hepatitis C Virus Co-Infection.
Document Type
article
Author
Source
PLoS Pathogens, Vol 11, Iss 12, p e1005325 (2015)
Subject
Language
English
ISSN
1553-7366
1553-7374
1553-7374
Abstract
Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Flaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generation sequencing of plasma from an HCV-infected patient with multiple bloodborne exposures who died from sepsis of unknown etiology. HPgV-2 is highly divergent, situated on a deep phylogenetic branch in a clade that includes rodent and bat pegiviruses, with which it shares