e-Article
Risk factors for cardiovascular disease among individuals with hepatic steatosis
Document Type
article
Author
Julia Karády; Maros Ferencik; Thomas Mayrhofer; Nandini M. Meyersohn; Daniel O. Bittner; Pedro V. Staziaki; Balint Szilveszter; Travis R. Hallett; Michael T. Lu; Stefan B. Puchner; Tracey G. Simon; Borek Foldyna; Geoffrey S. Ginsburg; Robert W. McGarrah; Deepak Voora; Svati H. Shah; Pamela S. Douglas; Udo Hoffmann; Kathleen E. Corey
Source
Hepatology Communications, Vol 6, Iss 12, Pp 3406-3420 (2022)
Subject
Language
English
ISSN
2471-254X
Abstract
Abstract Cardiovascular disease (CVD) is the leading cause of mortality in adults with hepatic steatosis (HS). However, risk factors for CVD in HS are unknown. We aimed to identify factors associated with coronary artery disease (CAD) and incident major adverse cardiovascular events (MACE) in individuals with HS. We performed a nested cohort study of adults with HS detected on coronary computed tomography in the PROspective Multicenter Imaging Study for Evaluation of chest pain (PROMISE) trial. Obstructive CAD was defined as ≥50% coronary stenosis. MACE included hospitalization for unstable angina, nonfatal myocardial infarction, or all‐cause death. Multivariate modeling, adjusted for age, sex, atherosclerotic CVD (ASCVD) risk score and body mass index, identified factors associated with obstructive CAD. Cox regression, adjusted for ASCVD risk score, determined the predictors of MACE. A total of 959 of 3,756 (mean age 59.4 years, 55.0% men) had HS. Obstructive CAD was present in 15.2% (145 of 959). Male sex (adjusted odds ratio [aOR] = 1.83, 95% confidence interval [CI] 1.18–1.2.84; p = 0.007), ASCVD risk score (aOR = 1.05, 95% CI 1.03–1.07; p