e-Article
Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease
Document Type
article
Author
Ana Sofía Ríos; Simón Oxenford; Clemens Neudorfer; Konstantin Butenko; Ningfei Li; Nanditha Rajamani; Alexandre Boutet; Gavin J. B. Elias; Jurgen Germann; Aaron Loh; Wissam Deeb; Fuyixue Wang; Kawin Setsompop; Bryan Salvato; Leonardo Brito de Almeida; Kelly D. Foote; Robert Amaral; Paul B. Rosenberg; David F. Tang-Wai; David A. Wolk; Anna D. Burke; Stephen Salloway; Marwan N. Sabbagh; M. Mallar Chakravarty; Gwenn S. Smith; Constantine G. Lyketsos; Michael S. Okun; William S. Anderson; Zoltan Mari; Francisco A. Ponce; Andres M. Lozano; Andreas Horn
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc analysis of multi-center cohorts to investigate the anatomical and functional correlates of effective deep brain stimulation, and find that stimulating circuit of Papez, fornix and bed nucleus of the stria terminalis, and a multi-region functional network, were associated with clinical improvement.