e-Article
The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
Document Type
article
Author
María Caldas; Ángeles Pérez-Aisa; Bojan Tepes; Alma Keco-Huerga; Luis Bujanda; Alfredo J. Lucendo; Luis Rodrigo; Dino Vaira; Luis Fernández-Salazar; Jose M. Huguet; Jorge Pérez-Lasala; Natasa Brglez Jurecic; Galina Fadeenko; Jesús Barrio; Miguel Areia; Juan Ortuño; Rinaldo Pellicano; Marcis Leja; Javier Molina-Infante; Pavel Bogomolov; Sergey Alekseenko; Manuel Domínguez-Cajal; Judith Gómez-Camarero; Vassiliki Ntouli; Samuel J. Martínez-Domínguez; Rafael Ruiz-Zorrilla; Oscar Núñez; Aiman Silkanovna Sarsenbaeva; Pedro Almela; Perminder Phull; Marta Espada; Ignasi Puig; Olga P. Nyssen; Francis Mégraud; Colm O’Morain; Javier P. Gisbert; on behalf of the Hp-EuReg Investigators
Source
Antibiotics, Vol 10, Iss 8, p 965 (2021)
Subject
Language
English
ISSN
2079-6382
Abstract
Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1–1.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59–0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4–2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3–5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates.