e-Article
Feasibility, safety, and impact of the RTS,S/AS01Emalaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi
Document Type
Article
Author
Asante, Kwaku Poku; Mathanga, Don P; Milligan, Paul; Akech, Samuel; Oduro, Abraham; Mwapasa, Victor; Moore, Kerryn A; Kwambai, Titus K; Hamel, Mary J; Gyan, Thomas; Westercamp, Nelli; Kapito-Tembo, Atupele; Njuguna, Patricia; Ansong, Daniel; Kariuki, Simon; Mvalo, Tisungane; Snell, Paul; Schellenberg, David; Welega, Paul; Otieno, Lucas; Chimala, Alfred; Afari, Edwin A; Bejon, Philip; Maleta, Kenneth; Agbenyega, Tsiri; Snow, Robert W; Zulu, Madaliso; Chinkhumba, Jobiba; Samuels, Aaron M; Abubakari, Sulemana Watara; Akumani, Albert; Adu-Gyasi, Dennis; Sarfo, Augustine; Odei-Lartey, Elezier; Agbokey, Francis; Amenga-Etego, Seeba; Gyaase, Stephany; Buabeng, Patrick; Awini, Elizabeth; Sylverken, Justice; Kampim, Aaron; Koram, Kwadwo A; Hodgson, Abraham; Binka, Fred Newton; Okine, Rafiq Nii Attoh; Tweneboah, Peter Ofori; Ondiegi, Bella; Seda, Brian; Akach, Dorcas; Orwa, Gordon; Nyang’au, Isabella; Odunga, Oscar; Gumba, Francis; Copeland, Nathanial; Khazenzi, Cynthia; Mumo, Eda; Musa, Monica; Ogero, Morris; English, Mike; Haji, Adam; Njoroge, Josephine; Msuku, Harrison; Samuel, Vincent; Mariko, Hillary Topazian; Juliano, Jon; Msumba, Lusungu; Mungwira, Randy George; Zimba, Boston Edward; Desai, Meghna; Furrer, Eliane; Aponte, John; Alonso, Pedro; Kalu, Akpaka A; Sillah, Jackson Sophianu
Source
The Lancet; April-May 2024, Vol. 403 Issue: 10437 p1660-1670, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
The RTS,S/AS01Emalaria vaccine (RTS,S) was introduced by national immunisation programmes in Ghana, Kenya, and Malawi in 2019 in large-scale pilot schemes. We aimed to address questions about feasibility and impact, and to assess safety signals that had been observed in the phase 3 trial that included an excess of meningitis and cerebral malaria cases in RTS,S recipients, and the possibility of an excess of deaths among girls who received RTS,S than in controls, to inform decisions about wider use.