e-Article
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial
Document Type
Article
Author
Lyttle, Mark D; Rainford, Naomi E A; Gamble, Carrol; Messahel, Shrouk; Humphreys, Amy; Hickey, Helen; Woolfall, Kerry; Roper, Louise; Noblet, Joanne; Lee, Elizabeth D; Potter, Sarah; Tate, Paul; Iyer, Anand; Evans, Vicki; Appleton, Richard E; Pereira, Matthew; Hardwick, Susie; Messahel, Shrouk; Noblet, Joanne; Lee, Elizabeth D; Greenwood-Bibby, Rachel; Buchanan, Mark; Lewis, Lucy; Hughes, Sharon; Hartshorn, Stuart; Rogers, Louise; Hopkins, Juliet; Lyttle, Mark D; Fernandez, Daphin; Potter, Sarah; Lavigne-Smith, Holly R; Moulsdale, Phoebe; Smith, Alice; Bingham, Tracey; Ross, James; Ramsey, Natasha; Hacking, Jo; Mullen, Niall; Corrigan, Paul P; Prudhoe, Sarah; Faza, Hani; Robinson, Gisela; Sunley, Rachel C; Smith, Coral J; Unsworth, Vanessa; Criddle, John; Laque, Martin; Sheedy, Alyce B; Anderson, Mark; Bell, Kathryn; Devine, Kirsty; Scott, Alex; Kumar, Ramesh; Armstrong, Sonia; Sutherland, Emer; Cantle, Fleur; Helyer, Sinead; Riozzi, Paul; Cotton, Hannah; Downes, Alice J; Mollard, Helen; Roland, Damian; Hay, Felix; Gough, Christopher; Finucane, Sonya; Bevan, Catherine; Ramsay, Rebecca; Walton, Emily; Maney, Julie-Ann; Dalzell, Elizabeth; Millar, Muriel; Howells, Rachel J; Appelboam, Andy; Mackle, Daisy; Small, Jennie; Neil, Ashleigh; Choudhery, Vince; MacLeod, Stewart; Browning, Jen; O'Neill, Thomas; Grahamslaw, Julia; Parikh, Ami; Skene, Imogen; Thomas, Rhys; Potier de la Morandiere, Katherine; Wilson, Jill L; Danziger, Donna; Burke, Derek; Ramlakhan, Shammi; Evans, Jayne; Morcombe, Julie; Gormley, Stuart; Barling, Jason M; Cathie, Katrina; Bayreuther, Jane; Ensom, Ruth; Iqbal, Yasser; Rounding, Sarah; Mulligan, Joanne; Bell, Claire; McLellan, Shona; Leighton, Shona; Sajjanhar, Tina; Nyirenda, Maggie; Crome, Laura; Williamson, Neil; Alcock, Anastasia; Edwards, Sara; Morgan, Jeff; Powell, Colin VE; Ramesh, Chaniyil A; Kamal-Uddin, Solomon; Linney, Mike; Vamvakiti, Katia; Floyd, Sharon; Hobden, Gill
Source
The Lancet; May 2019, Vol. 393 Issue: 10186 p2125-2134, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status epilepticus.