e-Article
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
Document Type
Article
Author
Keir, Holly R; Long, Merete B; Abo-Leyah, Hani; Giam, Yan Hui; Vadiveloo, Thenmalar; Pembridge, Thomas; Hull, Rebecca C; Delgado, Lilia; Band, Margaret; McLaren-Neil, Fiona; Adamson, Simon; Lahnsteiner, Eva; Gilmour, Amy; Hughes, Chloe; New, Benjamin JM; Connell, David; Dowey, Rebecca; Turton, Helena; Richardson, Hollian; Cassidy, Diane; Cooper, Jamie; Suntharalingam, Jay; Diwakar, Lavanya; Russell, Peter; Underwood, Jonathan; Hicks, Alexander; Dosanjh, Davinder PS; Sage, Beth; Dhasmana, Devesh; Spears, Mark; Thompson, AA Roger; Brightling, Christopher; Smith, Andrew; Patel, Manish; George, Jacob; Condliffe, Alison M; Shoemark, Amelia; MacLennan, Graeme; Chalmers, James D; Chalmers, James; Abo-Leyah, Hani; New, Benjamin JM; Almaden-Boyle, Christine; Connell, David; Taylor, Jennifer; Strachan, Jodie; Loftus, Heather; Young, Lesley; Strachan, Angela; Band, Margaret; McLaren-Neil, Fiona; Pilvinyte, Kristina; Adamson, Simon; Lahnsteiner, Eva; Rauchhaus, Petra; Hogarth, Fiona; George, Jacob; Burns, Tricia; Coote, Elizabeth; Keiller, Marney; Patel, Manish; Smith, Andrew; Sage, Elizabeth; Cooper, Jamie; Miller, David; Dosanjh, Davinder; Sutton, Benjamin; Underwood, Jonathan; Frayling, Sharon; Haynes, Matthew; Broad, Lauren; Jones, Laura; Rahilly, Karen; Oliver, Catherine; Evans, Terriann; Balan, Andrea; Davies, Rhys; Forde, Donal; Nye, Clemency; Haboubi, Dr; Hilton, Zoe; Williams, Jennie; McQueen, Alison; Spears, Mark; Edmond, Ian; Salutous, Dario; McGenily, Laura; Scott, Rhona; Henderson, Eilidh; Collins, Andrea; Dhasmana, Devesh; Liu, Patrick; Morrow, Ana; Couser, Mandy; Davey, Fleur; Hicks, Alexander; Wiffen, Laura; Fox, Lauren; Abdelrahim, Mohamed; Darbyshire, Alexander; Cowen, Elena; Rowley, Megan; Giles, Benjamin; Yang, Yingjia; Brown, Tom; Rupani, Hitasha; Hawes, Elizabeth; Barnes, Debi; Brogan, Fiona; Bungue-Tuble, Roneleeh; Howe, Serena; Turner, Charlotte; Baryschpolec, Sonia; Longhurst, Bev; Moon, Maria; Watkins, Lynn; Baker-Moffat, Michelle; Murray, Lisa; Harrington-Davies, Yasmin; Burrows, Kate; Minnis, Chrissie; Wands, Mary; Bamgboye, Adefunke; Wong, Charlotte; Brightling, Christopher; Diver, Sarah; Russell, Richard; McAuley, Hamish; Elneima, Omer; Yousuf, Ahmed; McCourt, Paula; Hargadon, Beverley; Parker, Sarah; Bourne, Michelle; Suntharalingam, Jay; Hartley, Tom; Masan, Vidan; Sturney, Sharon; MacKenzie, Rob; Marchand, Clare; Mason, Rebecca; White, Katie; Kirby, Alison; Meda, Manjula; Diwakar, Lavanya; Russell, Peter; Finn, Joanne; Harris, Sophie; Muir, Carol; Cook, Gemma; Staines, Nikki; Cook, Chris; Thompson, AA Roger; Condliffe, Alison; Hull, Rebecca; Dowey, Rebecca; Turton, Helena; Collini, Paul; Gabriel, Zoé; Hardman, Simon; Newell, Helen; Middle, Janet; Simpson, Phillip; Colton, Hayley; Barker, Joann; Birchall, Katie; Harrington, Kate; Housley, Kay; Lenagh, Rebecca; Wilson, Jayne; Wesonga, Joan; Whitham, Rachel; Bird, Sarah; Jackson, Yvonne; Mbuyisa, Angeline; Anderson, Samantha; Wilson, Anna; Kibutu, Faith; Walker, Sara; Cawthron, Kay; Macharia, Irene; Smart, Lynne; Emery, Anna; Howell, Alice; Hurditch, Elizabeth; Ford, Amber; Turner, Kim; Watson, Lisa; Bowler, Helen; Jackson, Tracy; Jaques, Carol; Dyer, Nichole; Ducker, Shelley; Goodall, Vicky; Udale, Emily
Source
The Lancet Respiratory Medicine; December 2022, Vol. 10 Issue: 12 p1119-1128, 10p
Subject
Language
ISSN
22132600; 22132619
Abstract
Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and increased serine protease activity has been reported in severe and fatal infection. We investigated whether brensocatib, an inhibitor of dipeptidyl peptidase-1 (DPP-1; an enzyme responsible for the activation of neutrophil serine proteases), would improve outcomes in patients hospitalised with COVID-19.