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Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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Ray, Kausik K; Colhoun, Helen M; Szarek, Michael; Baccara-Dinet, Marie; Bhatt, Deepak L; Bittner, Vera A; Budaj, Andrzej J; Diaz, Rafael; Goodman, Shaun G; Hanotin, Corinne; Harrington, Robert A; Jukema, J Wouter; Loizeau, Virginie; Lopes, Renato D; Moryusef, Angèle; Murin, Jan; Pordy, Robert; Ristic, Arsen D; Roe, Matthew T; Tuñón, José; White, Harvey D; Zeiher, Andreas M; Schwartz, Gregory G; Steg, Philippe Gabriel; Schwartz, Gregory G.; Steg, Ph. Gabriel; Bhatt, Deepak L.; Bittner, Vera A.; Diaz, Rafael; Goodman, Shaun G.; Harrington, Robert A.; Jukema, J. Wouter; Szarek, Michael; White, Harvey D.; Zeiher, Andreas M.; Tricoci, Pierluigi; Roe, Matthew T.; Mahaffey, Kenneth W.; Edelberg, Jay M.; Hanotin, Corinne; Lecorps, Guillaume; Moryusef, Angèle; Pordy, Robert; Sasiela, William J.; Tamby, Jean-François; Aylward, Philip E.; Drexel, Heinz; Sinnaeve, Peter; Dilic, Mirza; Lopes, Renato D.; Gotcheva, Nina N.; Prieto, Juan-Carlos; Yong, Huo; López-Jaramillo, Patricio; Pećin, Ivan; Reiner, Zeljko; Ostadal, Petr; Viigimaa, Margus; Nieminen, Markku S.; Chumburidze, Vakhtang; Marx, Nikolaus; Danchin, Nicolas; Liberopoulos, Evangelos; Montenegro Valdovinos, Pablo Carlos; Tse, Hung-Fat; Kiss, Robert Gabor; Xavier, Denis; Zahger, Doron; Valgimigli, Marco; Kimura, Takeshi; Kim, Hyo Soo; Kim, Sang-Hyun; Erglis, Andrejs; Laucevicius, Aleksandras; Kedev, Sasko; Yusoff, Khalid; Ramos López, Gabriel Arturo; Alings, Marco; Halvorsen, Sigrun; Correa Flores, Roger M.; Budaj, Andrzej; Morais, Joao; Dorobantu, Maria; Karpov, Yuri; Ristic, Arsen D.; Chua, Terrance; Murin, Jan; Fras, Zlatko; Dalby, Anthony J.; Tuñón, José; de Silva, H. Asita; Hagström, Emil; Landmesser, Ulf; Chiang, Chern-En; Sritara, Piyamitr; Guneri, Sema; Parkhomenko, Alexander; Ray, Kausik K.; Moriarty, Patrick M.; Vogel, Robert; Chaitman, Bernard; Kelsey, Sheryl F.; Olsson, Anders G.; Rouleau, Jean-Lucien; Simoons, Maarten L.; Alexander, Karen; Meloni, Chiara; Rosenson, Robert; Sijbrands, Eric J.G.; Tricoci, Pierluigi; Alexander, John H.; Armaganijan, Luciana; Bagai, Akshay; Bahit, Maria Cecilia; Brennan, J. Matthew; Clifton, Shaun; DeVore, Adam D.; Deloatch, Shalonda; Dickey, Sheila; Dombrowski, Keith; Ducrocq, Grégory; Eapen, Zubin; Endsley, Patricia; Eppinger, Arleen; Harrison, Robert W.; Hess, Connie Ng; Hlatky, Mark A.; Jordan, Joseph Dedrick; Knowles, Joshua W.; Kolls, Bradley J.; Kong, David F.; Leonardi, Sergio; Lillis, Linda; Maron, David J.; Marcus, Jill; Mathews, Robin; Mehta, Rajendra H.; Mentz, Robert J.; Moreira, Humberto Graner; Patel, Chetan B.; Bernardez-Pereira, Sabrina; Perkins, Lynn; Povsic, Thomas J.; Puymirat, Etienne; Schuyler Jones, William; Shah, Bimal R.; Sherwood, Matthew W.; Stringfellow, Kenya; Sujjavanich, Darin; Toma, Mustafa; Trotter, Charlene; Van Diepen, Sean; Wilson, Matthew D.; Yan, Andrew T.; Schiavi, Lilia B.; Garrido, Marcelo; Alvarisqueta, Andrés F.; Sassone, Sonia A.; Bordonava, Anselmo P.; Alves De Lima, Alberto E.; Schmidberg, Jorge M.; Duronto, Ernesto A.; Caruso, Orlando C.; Novaretto, Leonardo P.; Hominal, Miguel Angel; Montaña, Oscar R.; Caccavo, Alberto; Gomez Vilamajo, Oscar A.; Lorenzatti, Alberto J.; Cartasegna, Luis R.; Paterlini, Gustavo A.; Mackinnon, Ignacio J.; Caime, Guillermo D.; Amuchastegui, Marcos; Salomone, Oscar; Codutti, Oscar R.; Jure, Horacio O.; Bono, Julio OE; Hrabar, Adrian D.; Vallejos, Julio A.; Ahuad Guerrero, Rodolfo A.; Novoa, Federico; Patocchi, Cristian A.; Zaidman, Cesar J.; Giuliano, Maria E.; Dran, Ricardo D.; Vico, Marisa L.; Carnero, Gabriela S.; Guzman, Pablo N.; Medrano Allende, Juan C.; Garcia Brasca, Daniela F.; Bustamante Labarta, Miguel H; Nani, Sebastian; Blumberg, Eduardo DS; Colombo, Hugo R; Liberman, Alberto; Fuentealba, Victorino; Luciardi, Hector L; Waisman, Gabriel D; Berli, Mario A; Garcia Duran, Ruben O; Cestari, Horacio G; Luquez, Hugo A; Giordano, Jorge A; Saavedra, Silvia S; Zapata, Gerardo; Costamagna, Osvaldo; Llois, Susana; Waites, Jonathon H; Collins, Nicholas; Soward, Allan; Hii, Chris LS; Shaw, James; Arstall, Margaret A; Horowitz, John; Ninio, Daniel; Rogers, James F; Colquhoun, David; Oqueli Flores, Romulo E; Roberts-Thomson, Philip; Raffel, Owen; Lehman, Sam J; Aroney, Constantine; Coverdale, Steven GM; Garrahy, Paul J; Starmer, Gregory; Sader, Mark; Carroll, Patrick A; Dick, Ronald; Zweiker, Robert; Hoppe, Uta; Huber, Kurt; Berger, Rudolf; Delle-Karth, Georg; Frey, Bernhard; Weidinger, Franz; Faes, Dirk; Hermans, Kurt; Pirenne, Bruno; Leone, Attilio; Hoffer, Etienne; Vrolix, Mathias CM; De Wolf, Luc; Wollaert, Bart; Castadot, Marc; Dujardin, Karl; Beauloye, Christophe; Vervoort, Geert; Striekwold, Harry; Convens, Carl; Roosen, John; Barbato, Emanuele; Claeys, Marc; Cools, Frank; Terzic, Ibrahim; Barakovic, Fahir; Midzic, Zlatko; Pojskic, Belma; Fazlibegovic, Emir; Kulić, Mehmed; Durak-Nalbantic, Azra; Vulic, Dusko; Muslibegovic, Adis; Goronja, Boris; Reis, Gilmar; Sousa, Luciano; Nicolau, Jose C; Giorgeto, Flavio E; Silva, Ricardo P; Nigro Maia, Lilia; Rech, Rafael; Rossi, Paulo RF; Cerqueira, Maria José AG; Duda, Norberto; Kalil, Renato; Kormann, Adrian; Abrantes, José Antonio M; Pimentel Filho, Pedro; Soggia, Ana Priscila; de Santos, Mayler ON; Neuenschwander, Fernando; Bodanese, Luiz C; Michalaros, Yorghos L; Eliaschewitz, Freddy G; Vidotti, Maria H; Leaes, Paulo E; Botelho, Roberto V; Kaiser, Sergio; Manenti, Euler Roberto Fernandes; Precoma, Dalton B; Moura Jorge, Jose C; de B Silva, Pedro G; Silveira, Jose A; Saporito, Wladmir; Marin-Neto, Jose A; Feitosa, Gilson S; Ritt, Luiz Eduardo F; de Souza, Juliana A; Costa, Fernando; Souza, Weimar KSB; Reis, Helder JL; Machado, Leandro; Ayoub, José Carlos Aidar; Todorov, Georgi V; Nikolov, Fedya P; Velcheva, Elena S; Tzekova, Maria L; Benov, Haralambi O; Petranov, Stanislav L; Tumbev, Haralin S; Shehova-Yankova, Nina S; Markov, Dimitar T; Raev, Dimitar H; Mollov, Mihail N; Kichukov, Kostadin N; Ilieva-Pandeva, Katya A; Ivanova, Raya; Gospodinov, Maryana; Mincheva, Valentina M; Lazov, Petar V; Dimov, Bojidar I; Senaratne, Manohara; Stone, James; Kornder, Jan; Pearce, Stephen; Dion, Danielle; Savard, Daniel; Pesant, Yves; Pandey, Amritanshu; Robinson, Simon; Gosselin, Gilbert; Vizel, Saul; Hoag, Gordon; Bourgeois, Ronald; Morisset, Anne; Sabbah, Eric; Sussex, Bruce; Kouz, Simon; MacDonald, Paul; Diaz, Ariel; Michaud, Nicolas; Fell, David; Leung, Raymond; Vuurmans, Tycho; Lai, Christopher; Nigro, Frank; Davies, Richard; Nogareda, Gustavo; Vijayaraghavan, Ram; Ducas, John; Lepage, Serge; Mehta, Shamir; Cha, James; Dupuis, Robert; Fong, Peter; Lutchmedial, Sohrab; Rodes-Cabau, Josep; Fadlallah, Hussein; Cleveland, David; Huynh, Thao; Bata, Iqbal; Hameed, Adnan; Pincetti, Cristian; Potthoff, Sergio; Prieto, Juan C; Acevedo, Monica; Aguirre, Arnoldo; Vejar, Margarita; Yañez, Mario; Araneda, Guillermo; Fernandez, Mauricio; Perez, Luis; Varleta, Paola; Florenzano, Fernando; Huidobro, Laura; Raffo, Carlos A; Olivares, Claudia; Nahuelpan, Leonardo; Montecinos, Humberto; Chen, Jiyan; Dong, Yugang; Huang, Weijian; Wang, Jianzhong; Huang, Shi'An; Yao, Zhuhua; Li, Xiang; Cui, Lan; Lin, Wenhua; Sun, Yuemin; Wang, Jingfeng; Li, Jianping; Zhang, Xuelian; Zhu, Hong; Chen, Dandan; Huang, Lan; Dong, Shaohong; Su, Guohai; Xu, Biao; Su, Xi; Cheng, Xiaoshu; Lin, Jinxiu; Zong, Wenxia; Li, Huanming; Feng, Yi; Xu, Dingli; Yang, Xinchun; Ke, Yuannan; Lin, Xuefeng; Zhang, Zheng; Zheng, Zeqi; Luo, Zhurong; Chen, Yundai; Ding, Chunhua; Zhong, Yi; Zheng, Yang; Li, Xiaodong; Peng, Daoquan; Zhao, Shuiping; Li, Ying; Liu, Xuebo; Wei, Meng; Liu, Shaowen; Yu, Yihua; Qu, Baiming; Jiang, Weihong; Zhou, Yujie; Zhao, Xingsheng; Yuan, Zuyi; Guo, Ying; Xu, Xiping; Shi, Xubo; Ge, Junbo; Fu, Guosheng; Bai, Feng; Fang, Weiyi; Shou, Xiling; Yang, Xiangjun; Wang, Jian'An; Xiang, Meixiang; Sun, Yingxian; Lu, Qinghua; Zhang, Ruiyan; Zhu, Jianhua; Xu, Yizhou; Fan, Zhongcai; Li, Tianchang; Wu, Chun; Jaramillo, Nicolas; Sanchez Vallejo, Gregorio; Luna Botia, Diana C; Botero Lopez, Rodrigo; Molina De Salazar, Dora I; Cadena Bonfanti, Alberto J; Cotes Aroca, Carlos; Diego Higuera, Juan; Blanquicett, Marco; Barrera Silva, Sandra I; Garcia Lozada, Henry J; Coronel Arroyo, Julian A; Accini Mendoza, Jose L; Fernandez Ruiz, Ricardo L; Quintero Ossa, Alvaro M.; Manzur Jatin, Fernando G; Sotomayor Herazo, Aristides; Castellanos Parada, Jeffrey; Suarez Arambula, Rafael; Urina Triana, Miguel A; Fernandez Trujillo, Angela M; Strozzi, Maja; Car, Siniša; Jerić, Melita; Miličić, Davor; Benčić, Martina Lovrić; Pintarić, Hrvoje; Prvulović, Đeiti; Šikić, Jozica; Peršić, Viktor; Mileta, Dean; Štambuk, Kresimir; Babić, Zdravko; Tomulic, Vjekoslav; Lukenda, Josip; Mejic-Krstulovic, Stanka; Starcevic, Boris; Spinar, Jindrich; Horak, David; Velicka, Zdenek; Stasek, Josef; Alan, David; Machova, Vilma; Linhart, Ales; Novotny, Vojtech; Kaucak, Vladimir; Rokyta, Richard; Naplava, Robert; Coufal, Zdenek; Adamkova, Vera; Podpera, Ivo; Zizka, Jiri; Motovska, Zuzana; Marusincova, Ivana; Svab, Premysl; Heinc, Petr; Kuchar, Jiri; Povolny, Petr; Matuska, Jiri; Poulsen, Steen H; Raungaard, Bent; Clemmensen, Peter; Bang, Lia E; May, Ole; Bøttcher, Morten; Hove, Jens D; Frost, Lars; Gislason, Gunnar; Larsen, John; Betton Johansen, Peter; Hald, Flemming; Johansen, Peter; Jeppesen, Jørgen; Nielsen, Tonny; Kristensen, Kjeld S; Walichiewicz, Piotr Maria; Lomholdt, Jens D; Klausen, Ib C; Nielsen, Peter Kaiser; Davidsen, Flemming; Videbaek, Lars; Soots, Mai; Vahula, Veiko; Hedman, Anu; Soopõld, Üllar; Märtsin, Kaja; Jurgenson, Tiina; Kristjan, Arved; Helsinki, Juhani K; Vikman, Saila; Huikuri, Heikki; Airaksinen, Juhani; Coste, Pierre; Ferrari, Emile; Morel, Olivier; Montalescot, Gilles; Machecourt, Jacques; Barone-Rochette, Gilles; Mansourati, Jacques; Cottin, Yves; Leclercq, Florence; Belhassane, Abdelkader; Delarche, Nicolas; Boccara, Franck; Paganelli, Franck; Clerc, Jérôme; Schiele, Francois; Aboyans, Victor; Probst, Vincent; Berland, Jacques; Lefèvre, Thierry; Citron, Bernard; Khintibidze, Irakli; Shaburishvili, Tamaz; Pagava, Zurab; Ghlonti, Ramaz; Lominadze, Zaza; Khabeishvili, George; Hemetsberger, Rayyan; Edward, Kemala; Rauch-Kröhnert, Ursula; Stratmann, Matthias; Appel, Karl-Friedrich; Schmidt, Ekkehard; Omran, Heyder; Stellbrink, Christoph; Dorsel, Thomas; Lianopoulos, Emmanouil; Vöhringer, Hans Friedrich; Marx, Roger; Zirlik, Andreas; Schellenberg, Detlev; Heitzer, Thomas; Laufs, Ulrich; Werner, Christian; Marx, Nikolaus; Gielen, Stephan; Nuding, Sebastian; Winkelmann, Bernhard; Behrens, Steffen; Sydow, Karsten; Karakas, Mahir; Simonis, Gregor; Muenzel, Thomas; Werner, Nikos; Leggewie, Stefan; Böcker, Dirk; Braun-Dullaeus, Rüdiger; Toursarkissian, Nicole; Jeserich, Michael; Weißbrodt, Matthias; Schaeufele, Tim; Weil, Joachim; Völler, Heinz; Waltenberger, Johannes; Natour, Mohammed; Schmitt, Susanne; Müller-Wieland, Dirk; Steiner, Stephan; Heidenreich, Lothar; Offers, Elmar; Gremmler, Uwe; Killat, Holger; Rieker, Werner; Patsilinakos, Sotiris; Kartalis, Athanasios; Manolis, Athanassios; Sionis, Dimitrios; Chachalis, Geargios; Skoumas, Ioannis; Athyros, Vasilios; Vardas, Panagiotis; Parthenakis, Frangkiskos; Alexopoulos, Dimitrios; Hahalis, Georgios; Lekakis, John; Hatzitolios, Apostolos; Fausto Ovando, Sergio R; Arango Benecke, Juan L; Rodriguez De Leon, Edgar R; Yan, Bryan PY; Siu, David CW; Turi, Tibor; Merkely, Bela; Ungi, Imre; Lupkovics, Geza; Nagy, Lajos; Katona, András; Édes, István; Müller, Gábor; Horvath, Iván; Kapin, Tibor; Szigeti, Zsolt; Faluközy, József; Kumbla, Mukund; Sandhu, Manjinder; Annam, Sharath; Proddutur, Naveen Reddy; Regella, Reddy; Premchand, Rajendra K; Mahajan, Ajaykumar; Pawar, Sudhir; Abhyanakar, Atul D; Kerkar, Prafulla; Govinda, Ravishankar A; Oomman, Abraham; Sinha, Dhurjati; Patil, Sachin N; Kahali, Dhiman; Sawhney, Jitendra; Joshi, Abhijeet B; Chaudhary, Sanjeev; Harkut, Pankaj; Guha, Santanu; Porwal, Sanjay; Jujjuru, Srimannarayana; Pothineni, Ramesh B; Monteiro, Minguel R; Khan, Aziz; Iyengar, Shamanna S; Grewal, Jasprakash Singh; Chopda, Manoj; Fulwani, Mahesh C; Patange, Aparna; Sachin, Patil; Chopra, Vijay K; Goyal, Naresh K; Shinde, Rituparna; Manakshe, Gajendra V; Patki, Nitin; Sethi, Sumeet; Munusamy, Vengatesh; Karna, Sunil; Thanvi, Sunil; Adhyapak, Srilakshmi; Patil, Chandrakant; Pandurangi, Ulhas; Mathur, Rishabh; Gupta, Jugal; Kalashetti, Suhas; Bhagwat, Ajit; Raghuraman, Bagirath; Yerra, Shiv Kumar; Bhansali, Prasant; Borse, Rohidas; Rahul, Patil; Das, Srihari; Kumar, Vinay; Abdullakutty, Jabir; Saathe, Shireesh; Palimkar, Priya; Sathe, Shireesh; Atar, Shaul; Shechter, Michael; Mosseri, Morris; Arbel, Yaron; Ehud, Chorin; Ofer, Havakuk; Lotan, Chaim; Rosenschein, Uri; Katz, Amos; Henkin, Yaakov; Francis, Adi; Klutstein, Marc; Nikolsky, Eugenia; Zukermann, Robert; Turgeman, Yoav; Halabi, Majdi; Marmor, Alon; Kornowski, Ran; Jonas, Michael; Amir, Offer; Hasin, Yonathan; Rozenman, Yoseph; Fuchs, Shmuel; Zvi, Vered; Hussein, Osamah; Gavish, Dov; Vered, Zvi; Caraco, Yoseph; Elias, Mazen; Tov, Naveh; Wolfovitz, Efrat; Lishner, Michael; Elias, Nizar; Piovaccari, Giancarlo; De Pellegrin, Annamaria; Garbelotto, Raffaella; Guardigli, Gabriele; Marco, Valgimigli; Licciardello, Giovanni; Auguadro, Carla; Scalise, Filippo; Cuccia, Claudio; Salvioni, Alessandro; Musumeci, Giuseppe; Senni, Michelle; Calabrò, Paolo; Novo, Salvatore; Faggiano, Pompilio; Metra, Marco; De Cesare, Nicoletta B; Berti, Sergio; Cavallini, Claudio; Puccioni, Enrico; Galvani, Marcello; Tespili, Maurizio; Piatti, Piermarco; Palvarini, Michela; De Luca, Giuseppe; Violini, Roberto; De Leo, Alessandro; Olivari, Zoran; Perrone Filardi, Pasquale; Ferratini, Maurizio; Racca, Vittorio; Dai, Kazuoki; Shimatani, Yuji; Kamiya, Haruo; Ando, Kenji; Takeda, Yoshihiro; Morino, Yoshihiro; Hata, Yoshiki; Kimura, Kazuo; Kishi, Koichi; Michishita, Ichiro; Uehara, Hiroki; Higashikata, Toshinori; Hirayama, Atsushi; Hirooka, Keiji; Doi, Yasuji; Sakagami, Satoru; Taguchi, Shuichi; Koike, Akihiro; Fujinaga, Hiroyuki; Koba, Shinji; Kozuma, Ken; Kawasaki, Tomohiro; Ono, Yujiro; Shimizu, Masatoshi; Katsuda, Yousuke; Wada, Atsuyuki; Shinke, Toshiro; Kimura, Takeshi; Ako, Junya; Fujii, Kenshi; Takahashi, Toshiyuki; Sakamoto, Tomohiro; Nakao, Koichi; Furukawa, Yutaka; Sugino, Hiroshi; Tamura, Ritsu; Mano, Toshiaki; Uematsu, Masaaki; Utsu, Noriaki; Ito, Kashima; Haraguchi, Takuya; Sato, Katsuhiko; Ueda, Yasunori; Nishibe, Akira; Fujimoto, Kazuteru; Masutani, Motomaru; Yoon, Jung Han; Kim, Hack-Lyoung; Park, Hun Sik; Chae, In-Ho; Kim, Moo Hyun; Jeong, Myung Ho; Rha, Seungwoon; Kim, Chongjin; Kim, Hyo-Soo; Kim, Hae Young; Hong, Taekjong; Tahk, Seung-Jea; Kim, Youngkwon; Busmane, Arija; Pontaga, Natalija; Strelnieks, Aldis; Mintale, Iveta; Sime, Iveta; Petrulioniene, Zaneta; Kavaliauskiene, Roma; Jurgaitiene, Ruta; Sakalyte, Gintare; Slapikas, Rimvydas; Norkiene, Sigute; Misonis, Nerijus; Kibarskis, Aleksandras; Kubilius, Raimondas; Bojovski, Stojko; Lozance, Nensi; Kjovkaroski, Aleksandar; Doncovska, Snezana; Ong, Tiong Kiam; Kasim, Sazzli; Maskon, Oteh; Kandasamy, Balachandran; Liew, Houng B; Wan Mohamed, Wan Mohd Izani; García Castillo, Armando; Carrillo Calvillo, Jorge; Fajardo Campos, Pedro; Núñez Fragoso, Juan Carlos; Bayram Llamas, Edmundo Alfredo; Alcocer Gamba, Marco Antonio; Carranza Madrigal, Jaime; González Salas, Luis Gerardo; López Rosas, Enrique; González Díaz, Belinda; Salcido Vázquez, Eduardo; Nacoud Ackar, Alfredo; Llamas Esperón, Guillermo Antonio; Martínez Sánchez, Carlos Rodolfo; Guerrero De Leon, María; Suarez Otero, Rodrigo; Fanghänel Salmón, Guillermo; Pérez Ríos, Jesús Antonio; Garza Ruíz, José Angel; Breedveld, Robert W; Feenema-Aardema, Margriet; Borger-Van Der Burg, Alida; Hoogslag, Pieter AM; Suryapranata, Harry; Oomen, Antonius; Van Haelst, Paulus; Wiersma, Jacobijne J; Basart, Dirk; Van Der Wal, Ruud MA; Zwart, Peter; Monraats, Pascalle; Van Kesteren, Henricus; Karalis, Ioannis; Jukema, Johan; Verdel, Gerardus JE; Brueren, Bart RG; Troquay, Roland PTh; Viergever, Eric P; Al-Windy, Nadea YY; Bartels, Gerard L; Cornel, Jan H; Hermans, Walter RM; Herrman, Johannes PR; Bos, Robert J; Groutars, Reginald GEJ; Van Der Zwaan, Coenraad C; Kaplan, Refik; Lionarons, Raymond; Ronner, Eelko; Groenemeijer, Bjorn E; Bronzwaer, Patrick NA; Liem, Anho AH; Rensing, Bernard JWM; Bokern, Marcel JJA; Nijmeijer, Remco; Hersbach, Ferry MRJ; Willems, Frank F; Gosselink, Antonius TM; Rasoul, Saman; Elliott, John; Wilkins, Gerard; Fisher, Raewyn; Scott, Douglas; Hart, Hamish; Stewart, Ralph; Harding, Scott; Ternouth, Ian; Fisher, Nicholas; Wilson, Samuel; Aitken, Denise; Anscombe, Russell; Davidson, Laura; Tomala, Tadeusz; Nygård, Ottar; Sparby, Jon Arne; Andersen, Kjell; Gullestad, Lars; Jortveit, Jarle; Munk, Peter S; Singsaas, Erlend gyllensten; Hurtig, Ulf; Calderon Ticona, Jorge R; Durand Velasquez, Julio R; Negron Miguel, Sandra A; Sanabria Perez, Enrique S; Carrion Chambilla, Jesus M; Chavez Ayala, Carlos A; Castillo Leon, Reynaldo P; Vargas Gonzales, Rolando J; Hernandez Zuniga, Jose D; Camacho Cosavalente, Luis A; Bravo Mannucci, Jorge E; Heredia Landeo, Javier; Llerena Navarro, Nassip C; Roldan Concha, Yudy M; Rodriguez Chavez, Víctor E; Anchante Hernandez, Henry A; Zea Nunez, Carlos A; Mogrovejo Ramos, Walter; Ferrolino, Arthur; Sy, Rosa Allyn G; Tirador, Louie; Sy, Rody G; Matiga, Generoso; Coching, Raul Martin; Bernan, Alisa; Rogelio, Gregorio; Morales, Dante D.; Tan, Edgar; Sulit, Dennis Jose; Wlodarczak, Adrian; Jaworska, Krystyna; Skonieczny, Grzegorz; Pawlowicz, Lidia; Wojewoda, Pawel; Busz-Papiez, Benita; Bednarski, Janusz; Goch, Aleksander; Staneta, Pawel; Dulak, Elzbieta; Saminski, Krzysztof; Krasowski, Wlodzimierz; Sudnik, Wanda; Zurakowski, Aleksander; Skorski, Marcin; Miklaszewicz, Beata; Kubica, Jacek; Andrzej Lipko, Jan; Kostarska-Srokosz, Edyta; Piepiorka, Marek; Drzewiecka, Anna; Stasiewski, Arkadiusz; Blicharski, Tomasz; Bystryk, Leszek; Szpajer, Michal; Korol, Marek; Czerski, Tomasz; Mirek-Bryniarska, Ewa; Gniot, Jacek; Lubinski, Andrzej; Gorny, Jerzy; Franek, Edward; Raczak, Grzegorz; Szwed, Hanna; Monteiro, Pedro; Mesquita Bastos, Jose; Pereira, Helder H; Martins, Dinis; Seixo, Filipe; Mendonça, Carlos; Botelho, Ana; Caetano, Francisca; Minescu, Bogdan; Istratoaie, Octavian; Tesloianu, Dan N; Cristian, Gabriel; Dumitrescu, Silviu; Podoleanu, Cristian GC; Constantinescu, Mircea CA; Bengus, Cristina M; Militaru, Constantin; Rosu, Doina; Parepa, Irinel R; Matei, Adrian V; Alexandru, Tom M; Malis, Mihaela; Coman, Ioan; Stanescu-Cioranu, Rodica; Dimulescu, Doina; Shvarts, Yury; Orlikova, Olga; Kobalava, Zhanna; Barbarash, Olga L; Markov, Valentin; Lyamina, Nadezhda; Gordienko, Alexander; Zrazhevsky, Konstantin; Vishnevsky, Alexander Y; Gurevich, Victor; Stryuk, Raisa; Lomakin, Nikita V; Bokarev, Igor; Khlevchuk, Tatiana; Shalaev, Sergey; Khaisheva, Larisa; Chizhov, Petr; Viktorova, Inna; Osokina, Natalya; Shchekotov, Vladimir; Akatova, Evgenia; Chumakova, Galina; Libov, Igor; Voevoda, Mikhail I; Tretyakova, Tatyana V; Baranov, Evgeny; Shustov, Sergey; Yakushin, Sergey; Gordeev, Ivan; Khasanov, Niiaz; Reshetko, Olga; Sotnikova, Tatiana; Molchanova, Olga; Nikolaev, Konstantin; Gapon, Liudmila; Baranova, Elena; Shogenov, Zaur; Kosmachova, Elena; Karpov, Yuriy; Povzun, Anton; Egorova, Liudmila; Tyrenko, Vadim V; Ivanov, Igor G; Ilya, Masterov; Kanorsky, Sergey; Simic, Dragan; Ivanovic, Nikola; Davidovic, Goran; Tasic, Nebojsa; Asanin, Milika R.; Stojic, Stevo; Apostolovic, Svetlana R.; Ilic, Stevan; Putnikovic Tosic, Biljana; Stankovic, Aleksandar; Arandjelovic, Aleksandra; Radovanovic, Slavica; Todic, Branislava; Balinovac, Jovan; Dincic, Dragan V.; Seferovic, Petar; Karadzic, Ana; Dodic, Slobodan; Dimkovic, Sinisa; Jakimov, Tamara; Poh, Kian-Keong; Ong, Hean Yee; Tang I-Shing, Justin; Micko, Karol; Nociar, Jan; Pella, Daniel; Fulop, Peter; Hranai, Marian; Palka, Juraj; Mazur, Juraj; Majercák, Ivan; Dzupina, Andrej; Fazekas, František; Gonsorcik, Jozef; Bugan, Viliam; Selecky, Juraj; Kamensky, Gabriel; Strbova, Jaroslava; Smik, Rudolf; Dukat, Andrej; Žuran, Ivan; Poklukar, Janez; Černič Šuligoj, Nataša; Cevc, Matija; Cyster, Henry P; Ranjith, Naresh; Corbett, Clive; Bayat, Junaid; Makotoko, Ellen Makoali; du Toit Theron, Hendrik; 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Source
The Lancet Diabetes & Endocrinology; August 2019, Vol. 7 Issue: 8 p618-628, 11p
Subject
Language
ISSN
22138587; 22138595
Abstract
After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes.