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e-Article

Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle‐associated M cells
Document Type
Article
Source
Experimental Physiology; November 1992, Vol. 77 Issue: 6 p929-932, 4p
Subject
Language
ISSN
09580670; 1469445X
Abstract
Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle‐associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) causes a fourfold reduction in adsorption and a twentyfold reduction in uptake. Results demonstrate selectivity between adsorption and uptake and between the ability of different proteins to facilitate uptake.