e-Article
Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial
Document Type
Article
Author
Böhm, Michael; Kario, Kazuomi; Kandzari, David E; Mahfoud, Felix; Weber, Michael A; Schmieder, Roland E; Tsioufis, Konstantinos; Pocock, Stuart; Konstantinidis, Dimitris; Choi, James W; East, Cara; Lee, David P; Ma, Adrian; Ewen, Sebastian; Cohen, Debbie L; Wilensky, Robert; Devireddy, Chandan M; Lea, Janice; Schmid, Axel; Weil, Joachim; Agdirlioglu, Tolga; Reedus, Denise; Jefferson, Brian K; Reyes, David; D'Souza, Richard; Sharp, Andrew S P; Sharif, Faisal; Fahy, Martin; DeBruin, Vanessa; Cohen, Sidney A; Brar, Sandeep; Townsend, Raymond R; Akarca, Ertan; Allaqaband, Suhail; Andrikou, Eirini; Aoki, Jiro; Arnold, Ahran; Aronow, Herbert; Asami, Masahiko; Bachinsky, William; Barton, John; Bass, Kyle; Batson, Bryan; Bell, Chris; Bertolet, Barry; Bewarder, Yvonne; Bihlmaier, Karl; Binner, Christian; Bloom, Jason; Blossom, Benjamin; Brar, Somjot; Brown, Angela; Burke, Robert; Burke, Martin N; Butler, Michael; Calhoun, William; Campbell, James; Carroll, Steve; Chapman, Neil; Chasen, Craig; Cheng, Shi-Chi; Chia, Beth; Choksi, Nishit; Cohen, Jordana; Connolly, Niall; Contreras, Johanna; Cusack, Ronan; Dangas, George; David, Shukri; Davies, Justin; Dederer, Juliane; Denker, Matthew; Desch, Udo; Didangelos, Matthaios; Dienemann, Thomas; Dimitriadis, Kyriakos; Dorval, Jean-François; Estess, John; Fan, Sarah; Fengler, Karl; Ferguson, Lee; Fudim, Marat; Fuster, Valentin; Garcia, Fidel; Garcia, Santiago; Garton, Alex; Gessler, Carl; Ghali, Magdi; Gummadi, Bharat; Gupta, Amit; Gutierrez, Antonio; Hardesty, Peggy; Hartung, Phillip; Haught, Walter H; Haun, Yonghong; Hays, Sara; Helmreich, Wolfgang; Hill, Douglas; Hopper, Ingrid; Horiuchi, Yu; Hoshide, Satoshi; Howard, James; Ikeda, Wanda; Jan, Fued; Jauhar, Rajiv; Jay, Desmond; Johnson, James; Johnston, Thomas; Jones, Schuyler; Jung, Susanne; Kalos, Theodoros; Kanitkar, Mihar; Kannenkeril, Dennis; Kasiakogias, Alexandros; Kazziha, Samer; Keene, Daniel; Khitha, Jayant; Kikushima, Hosei; Kobayashi, Taisei; Komiyama, Kota; Komori, Takahiro; Kotter, John; Kouparanis, Antonios; Krasnow, Joshua; Kulenthiran, Saarraangan; Kumar, Sarwan; L'Allier, Philippe; Laney, Phillip; Lauder, Lucas; Lavoie, Marc A; Lerche, Matthias; Linesky, Elena; Little, Nelson; Lomboy, Carl; Lucic, Jelena; Lurz, Philipp; Lynch, Shannon; Mansukhani, Prakash; McDuffie, Katie; McGrath, Brian; McLaurin, Brent; Meade, Ashley; Meraj, Perwaiz; Millenaar, Dominic; Moore, Naing; Mori, Fumiko; Munch, Phillip; Murphy, James; Murray, Jennifer; Nanjundappa, Aravinda; Ninomiya, Kai; Oba, Yusuke; O'Connor, Tim; Ogata, Yukiyo; Ogoyama, Yukako; Onsrud, Rachel; Ott, Christian; Padaliya, Bimal; Pagidipati, Neha; Patel, Manesh; Patel, Kiritkumar; Petteinidou, Emanouela; Porr, Wendy; Rao, Anjani; Razi, Rabia; Regan, Christopher; Remetz, Michael; Rizik, David; Robison, Monique; Rommel, Karl-Philipp; Rosseel, Liesbeth; Rothstein, Marcos; Rough, Randolph; Saavedra, Jose; Saba, Souhell; Schwartz, Robert; Selcer, Shaun; Sen, Sayan; Sennott, Jacqueline; Shadman, Ramin; Shah, Samit; Shemin, Douglas; Shimizu, Hayato; Shimpo, Masahisa; Shishehbor, Mehdi; Shun-Shin, Matthew; Sierra, Francisco; Singh, Jasvindar; Singh, Avneet; Sirajeldin, Yassir; Skeik, Nedaa; Soliman, George; Statton, Sarah; Stehli, Julia; Steigerwalt, Susan; Striepe, Kristina; Stuck, Jason; Suppan, Markus; Svetkey, Laura; Takker, Ganpat; Tanabe, Kengo; Tanaka, Tetsu; Tomii, Daijiro; Torre, Sabino; Traverse, Jay; Tyson, Crystal; Vasquez, Alejandro; Velasquez, Enrique; Vemulapalli, Sreekanth; Waki, Hirotaka; Walton, Tony; Wang, Yale; Weber, Thomas; Wells, Bryan; Wilkins, Robert; Wright, Thomas; Yahagi, Kazuyuki; Yeung, Alan; Zadegan, Ray; Zeller, Thomas; Ziada, Khaled; Ziakas, Antonios; Zidar, David
Source
The Lancet; May 2020, Vol. 395 Issue: 10234 p1444-1451, 8p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Catheter-based renal denervation has significantly reduced blood pressure in previous studies. Following a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of renal denervation in the absence of antihypertensive medications.