e-Article
Role of HLA-Bexon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study
Document Type
Article
Author
Petersdorf, Effie W; Carrington, Mary; O'hUigin, Colm; Bengtsson, Mats; De Santis, Dianne; Dubois, Valerie; Gooley, Ted; Horowitz, Mary; Hsu, Katharine; Madrigal, J Alejandro; Maiers, Martin J; Malkki, Mari; McKallor, Caroline; Morishima, Yasuo; Oudshoorn, Machteld; Spellman, Stephen R; Villard, Jean; Stevenson, Phil; Petersdorf, Effie W; Carrington, Mary; O'hUigin, Colm; Bengtsson, Mats; De Santis, Dianne; Dubois, Valerie; Gooley, Ted; Horowitz, Mary; Hsu, Katharine; Madrigal, J Alejandro; Maiers, Martin; Malkki, Mari; McKallor, Caroline; Morishima, Yasuo; Oudshoorn, Machteld; Spellman, Stephen; Villard, Jean; Stevenson, Phil; Apperley, Jane; Bardy, Peter; Bernard, Ghislaine; Bertrand, Yves; Bloor, Adrian; Bonini, Chiara; Buhler, Stephane; Bungener, Laura; Campbell, Helen; Carlson, Kristina; Carpenter, Ben; Cesbron, Anne; Chabannon, Christian; Chalandon, Yves; Chapman, Jeremy; Chebel, Réda; Chevallier, Patrice; Choi, Gerda; Collin, Matt; Cornelissen, Jan J; Crawley, Charles; D'Orsogna, Lloyd; Dalle, Jean-Hugues; Deconinck, Eric; DeMatteis, Muriel; Diviney, Mary; Dormoy, Anne; Gagne, Katia; Gibson, Brenda; Gilleece, Maria; Gottlieb, David; Gribben, John; Güngör, Tayfun; Haagenson, Mike; Hart, Cathie; Holdsworth, Rhonda; Humphreys, Ian; Kodera, Yoshihisa; Koh, Mickey; Labussière-Wallet, Hélène; Lankester, Arjan C; Lardy, Neubery; Lawson, Sarah; Leleu, Xavier; MacKinnon, Stephen; Malladi, Ram; Marsh, Steven GE; Martin, Murray; Mayor, Neema P; McQuaker, I Grant; Meijer, Ellen; Morishima, Satoko; Nikolousis, Emmanouil; Orchard, Kim; Passweg, Jacob; Patel, Amit; Patrick, Katherine; Pedron, Béatrice; Peniket, Andy; Perry, Julia; Petersen, Eefke; Potter, Victoria; Potter, Mike; Protheroe, Rachel; Raus, Nicole; Ruiz de Elvira, Carmen; Russell, Nigel; Schaap, Nicholaas PM; Schanz, Urs; Schouten, Harry; Skinner, Roderick; Snowden, John; Spierings, Eric; Steward, Colin; Tholouli, Eleni; Thornton, Alycia; Tilanus, Marcel; van de Meer, Arnold; Veelkens, Hendrik; Veys, Paul; Watson, Narelle; Weston, Lyanne; Wilson, Keith; Wilson, Marie; Wynn, Robert; Zsiros, József
Source
The Lancet Haematology; January 2020, Vol. 7 Issue: 1 pe50-e60, 11p
Subject
Language
ISSN
23523026
Abstract
The success of unrelated haemopoietic cell transplantation (HCT) is limited by graft-versus-host disease (GVHD), which is the main post-transplantation challenge when HLA-matched donors are unavailable. A sequence dimorphism in exon 1 of HLA-Bgives rise to leader peptides containing methionine (Met; M) or threonine (Thr; T), which differentially influence natural killer and T-cell alloresponses. The main aim of the study was to evaluate the role of the leader dimorphism in GVHD after HLA-B-mismatched unrelated HCT.