e-Article
Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials
Document Type
Article
Author
Mayer-Hamblett, Nicole; Ratjen, Felix; Russell, Renee; Donaldson, Scott H; Riekert, Kristin A; Sawicki, Gregory S; Odem-Davis, Katherine; Young, Julia K; Rosenbluth, Daniel; Taylor-Cousar, Jennifer L; Goss, Christopher H; Retsch-Bogart, George; Clancy, John Paul; Genatossio, Alan; O'Sullivan, Brian P; Berlinski, Ariel; Millard, Susan L; Omlor, Gregory; Wyatt, Colby A; Moffett, Kathryn; Nichols, David P; Gifford, Alex H; Kloster, Margaret; Weaver, Katie; Chapdu, Claire; Xie, Jing; Skalland, Michelle; Romasco, Melita; Heltshe, Sonya; Simon, Noah; VanDalfsen, Jill; Mead, Anna; Buckingham, Rachael; Seidel, Kathy; Midamba, Nikita; Couture, Laurel; Case, Brooke Zappone; Au, Wendy; Rockers, Elsie; Cooke, Diane; Olander, Amber; Bondick, Irene; Johnson, Miya; VanHousen, Lisya; Nicholson, Boris; Omlor, Gregory; Parrish, Michelle; Roberts, Dion; Head, Jillian; Carey, Jessica; Caverly, Lindsay; Dangerfield, Joy; Linnemann, Rachel; Fullmer, Jason; Roman, Chelsea; Mogayzel, Peter; Reyes, Deanne; Harmala, Amy; Lysinger, Jerimiah; Bergeron, Jonathan; Virella-Lowell, Isabel; Brown, Perry; Godusevic, Lejla; Casey, Alicia; Paquette, Lauren; Lahiri, Thomas; Sweet, Julie; Donaldson, Scott; Harris, Joshua; Parnell, Shelia; Szentpetery, Sylvia; Froh, Deborah; Tharrington, Erica; Jain, Manu; Nelson, Rachel; Kadon, Sharon; McPhail, Gary; McBennett, Kimberly; Rone, Tia; Dasenbrook, Elliott; Weaver, Dave; Johnson, Terri; McCoy, Karen; Jain, Raksha; Mcleod, Maria; Klosterman, Mary; Sharma, Preeti; Jones, Amy; Mueller, Gary; Janney, Rachel; Taylor-Cousar, Jennifer; Cross, Mary; Hoppe, Jordana; Cahill, James; Mukadam, Zubin; Finto, Jill; Schultz, Karen; Villalta, Silvia Delgado; Smith, Alexa; Millard, Susan; Symington, Thomas; Graff, Gavin; Kitch, Diane; Sanders, Don; Thompson, Misty; Pena, Tahuanty; Teresi, Mary; Gafford, Jennifer; Schaeffer, David; Mermis, Joel; Scott, Lawrence; Escobar, Hugo; Williams, Kristen; Dorman, Dana; O'Sullivan, Brian; Bethay, Ryan; Danov, Zoran; Berlinski, Ariel; Turbeville, Kat; Johannes, Jimmy; Rodriguez, Angelica; Marra, Bridget; Zanni, Robert; Morton, Ronald; Simeon, Terri; Braun, Andrew; Dondlinger, Nicole; Biller, Julie; Hubertz, Erin; Antos, Nicholas; Roth, Laura; Billings, Joanne; Larson, Catherine; Balaji, Priya; McNamara, John; Clark, Tammy; Moffett, Kathryn; Griffith, Rebecca; Martinez, Nancy; Hussain, Sabiha; Malveaux, Halina; Egan, Marie; Guzman, Catalina; DeCelie-Germana, Joan; Galvin, Susan; Savant, Adrienne; Falgout, Nicole; Walker, Patricia; Demarco, Teresa; DiMango, Emily; Ycaza, Maria; Ballo, Julie; Tirakitsoontorn, Pornchai; Layish, Daniel; Serr, Desiree; Livingston, Floyd; Wooldridge, Sherry; Milla, Carlos; Spano, Jacquelyn; Davis, Rebecca; Elidemir, Okan; Chittivelu, Subramanyam; Scott, Ashley; Alam, Sarah; Dorgan, Daniel; Butoryak, Matt; Weiner, Daniel; Renna, Harmony; Wyatt, Colby; Klein, Brendan; Stone, Anne; Lessard, Meg; Schechter, Michael S.; Johnson, Barbara; Scofield, Steven; Liou, Theodore; Vroom, Jane; Akong, Kathryn; Gil, Marissa; Betancourt, Legna; Singer, Jonathan; Ly, Ngoc; Moreno, Courtney; Aitken, Moira; Gambol, Teresa; Genatossio, Alan; Gibson, Ronald; Lambert, Allison; Milton, Joan; Rosenbluth, Daniel; Smith, Sarah; Green, Deanna; Hodge, Diana; Fortner, Christopher; Forell, Mary; Karlnoski, Rachel; Patel, Kapil; Daines, Cori; Ryan, Elizabeth; Amaro-Galvez, Rodolfo; Dohanich, Elizabeth; Lennox, Alison; Messer, Zachary; Hanes, Holly; Powell, Kay; Polineni, Deepika
Source
The Lancet Respiratory Medicine; April 2023, Vol. 11 Issue: 4 p329-340, 12p
Subject
Language
ISSN
22132600; 22132619
Abstract
Reducing treatment burden is a priority for people with cystic fibrosis, whose health has benefited from using new modulators that substantially increase CFTR protein function. The SIMPLIFY study aimed to assess the effects of discontinuing nebulised hypertonic saline or dornase alfa in individuals using the CFTR modulator elexacaftor plus tezacaftor plus ivacaftor (ETI).