e-Article
Thyroid Hormone-Mediated Growth and Differentiation of Growth Plate Chondrocytes Involves IGF-1 Modulation of ß-Catenin Signaling.
Document Type
Article
Author
Source
Journal of Bone & Mineral Research; May2010, Vol. 25 Issue 5, p1138-1146, 9p, 5 Black and White Photographs, 1 Diagram, 5 Graphs
Subject
Language
ISSN
08840431
Abstract
The article discusses a study which examined the role of insulin-like growth factor 1 (IGF-1) signaling on the interaction between thyroid hormone and the Wnt/ß-catenin signaling pathways to regulate the proliferation and differentiation of growth plate chondrocytes. Results of the study showed that IGF-1 and the IGF-1 receptor stimulated the expression of Wnt-4 and the activation of ß-catenin in growth plate chondrocytes.